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Analysis of factors decreasing testis weight in MRL mice

http://hdl.handle.net/10659/2868
http://hdl.handle.net/10659/2868
1e1e2599-1d26-4901-ac61-4fbefc87b93a
名前 / ファイル ライセンス アクション
S-2011-148_Endo.pdf S-2011-148_Endo.pdf (223.4 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2012-10-01
タイトル
タイトル Analysis of factors decreasing testis weight in MRL mice
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Otsuka, Saori

× Otsuka, Saori

WEKO 4702

Otsuka, Saori

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Namiki, Yuka

× Namiki, Yuka

WEKO 4703

Namiki, Yuka

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Ichii, Osamu

× Ichii, Osamu

WEKO 4704

Ichii, Osamu

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Hashimoto, Yoshiharu

× Hashimoto, Yoshiharu

WEKO 4705

Hashimoto, Yoshiharu

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Sasaki, Nobuya

× Sasaki, Nobuya

WEKO 4706

Sasaki, Nobuya

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遠藤, 大二

× 遠藤, 大二

WEKO 4569
教員総覧 9420

en ENDO, Daiji

ja 遠藤, 大二


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Kon, Yasuhiro

× Kon, Yasuhiro

WEKO 4707

Kon, Yasuhiro

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抄録
内容記述タイプ Abstract
内容記述 MRL/MpJ (MRL) mouse testes have several unique characteristics, including the appearance of oocytes, the occurrence of metaphase-specific apoptosis of meiotic spermatocytes, and the presence of heat-shock-resistant spermatocytes. In the present study we used chromosomal mapping to determine the genomic background associated with small testis size in MRL mice. We prepared and analyzed C57BL/6-based congenic mice carrying MRL mouse loci. Quantitative trait loci (QTL) analysis revealed susceptibility loci for small testis size at 100 cM on chromosome (Chr) 1 and at around 80 cM on Chr 2. Analysis with B6.MRLc1 and B6.MRLc2 congenic mice and double-congenic mice confirmed the QTL data and showed that low testis weight in MRL mice was caused by germ cell apoptosis. Through histological examinations we found that B6.MRLc1 and B6.MRLc2 mice showed stage-specific apoptosis in their testes, the former at metaphase stage XII and the later at pachytene stage IV. Metaphase-specific apoptosis of spermatocytes occurs due to mutation of the exonuclease 1 (Exo1) gene located at 100 cM on Chr 1. Thus, the mutation of the Exo1 gene is also responsible for low testis weight caused by metaphase-specific apoptosis. In conclusion, testis weight is reduced in MRL mice due to apoptosis of germ cells caused by mutations in loci on Chrs 1 and 2.
書誌情報 Mammalian Genome

巻 21, 号 3-4, p. 153-161, 発行日 2010-04
ISSN
収録物識別子タイプ ISSN
収録物識別子 0938-8990
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 10.1007/s00335-010-9251-0
権利(URI)
権利情報 http://dx.doi.org/10.1007/s00335-010-9251-0 | http://dx.doi.org/10.1007/s00335-010-9251-0
著者版フラグ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
出版者
出版者 Springer
資源タイプ
内容記述タイプ Other
内容記述 Article
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