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Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in miceviamodulation of the inflammatory cytokines

http://hdl.handle.net/10659/3042
http://hdl.handle.net/10659/3042
2dcaa52a-f2f9-4d96-ae83-bc5746cf500f
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-06-04
タイトル
タイトル Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in miceviamodulation of the inflammatory cytokines
言語
言語 eng
キーワード
主題Scheme Other
主題 Astaxanthin
キーワード
主題Scheme Other
主題 Chemoprevention
キーワード
主題Scheme Other
主題 Colorectal carcinogenesis
キーワード
主題Scheme Other
主題 Inflammation
キーワード
主題Scheme Other
主題 Mouse
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Yasui, Yumiko

× Yasui, Yumiko

WEKO 5274

Yasui, Yumiko

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Hosokawa, Masashi

× Hosokawa, Masashi

WEKO 5275

Hosokawa, Masashi

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Mikami, Nana

× Mikami, Nana

WEKO 5276

Mikami, Nana

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Miyashita, Kazuo

× Miyashita, Kazuo

WEKO 5277

Miyashita, Kazuo

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Tanaka, Takuji

× Tanaka, Takuji

WEKO 5278

Tanaka, Takuji

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抄録
内容記述タイプ Abstract
内容記述 Astaxanthin (AX) is one of the marine carotenoid pigments, which possess powerful biological antioxidant, anti-inflammatory and anti-cancer properties. The purpose of this study is to investigate possible inhibitory effect of AX against inflammation-related mouse colon carcinogenesis and dextran sulfate sodium (DSS)-induced colitis in male ICR mice. We conducted two different experiments. In the first experiment, we evaluated the effects of AX at three dose levels, 50, 100 and 200 ppm in diet, on colitis-associated colon carcinogenesis induced by azoxymethane (AOM)/DSS in mice. In the second, the effects of the AX (100 and 200 ppm) in diet on DSS-induced colitis were determined. We found that dietary AX significantly inhibited the occurrence of colonic mucosal ulcers, dysplastic crypts, and colonic adenocarcinoma at week 20. AX-feeding suppressed expression of inflammatory cytokines, including nuclear factor (NF)-κB, tumor necrosis factor (TNF)-α and interleukin (IL)-1β, inhibited proliferation, and induced apoptosis in the colonic adenocarcinomas. Feeding with 200 ppm AX, but not 100 ppm, significantly inhibited the development of DSS-induced colitis. AX feeding (200 ppm in diet) also lowered the protein expression of NF-κB, and the mRNA expression of inflammatory cytokines, including IL-1β, IL-6, and cyclooxygenase (COX)-2. Our results suggest that the dietary AX suppresses the colitis and colitis-related colon carcinogenesis in mice, partly through inhibition of the expression of inflammatory cytokine and proliferation. Our findings suggest that AX is one of the candidates for prevention of colitis and inflammation-associated colon carcinogenesis in humans.
書誌情報 Chemico-Biological Interactions

巻 193, 号 1, p. 79-87, 発行日 2011-08
ISSN
収録物識別子タイプ ISSN
収録物識別子 0009-2797
DOI
識別子タイプ DOI
関連識別子 10.1016/j.cbi.2011.05.006
出版者
出版者 Elsevier
資源タイプ
内容記述タイプ Other
内容記述 Article
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