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Distribution of α(IV) collagen chains in the ocular anterior segments of adult mice

http://hdl.handle.net/10659/3040
http://hdl.handle.net/10659/3040
412b51bd-9964-430c-9ae1-8382fe081d01
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-06-04
タイトル
タイトル Distribution of α(IV) collagen chains in the ocular anterior segments of adult mice
言語
言語 eng
キーワード
主題Scheme Other
主題 collagen
キーワード
主題Scheme Other
主題 basement membrane
キーワード
主題Scheme Other
主題 eye
キーワード
主題Scheme Other
主題 ciliary body
キーワード
主題Scheme Other
主題 extracellular matrix
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Saito, Kenji

× Saito, Kenji

WEKO 5307

Saito, Kenji

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Yonezawa, Tomoko

× Yonezawa, Tomoko

WEKO 5308

Yonezawa, Tomoko

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MINAGUCHI, Jyun

× MINAGUCHI, Jyun

WEKO 5069
教員総覧 b3feebe96363a5f7b7ccf1252aa990bd

MINAGUCHI, Jyun

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Kurosaki, Masae

× Kurosaki, Masae

WEKO 5309

Kurosaki, Masae

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Suetsugu, Shiho

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WEKO 5310

Suetsugu, Shiho

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Nakajima, Ai

× Nakajima, Ai

WEKO 5311

Nakajima, Ai

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Nomoto, Hiroyuki

× Nomoto, Hiroyuki

WEKO 5312

Nomoto, Hiroyuki

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Morizane, Yuki

× Morizane, Yuki

WEKO 5313

Morizane, Yuki

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Sado, Yoshikazu

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WEKO 5314

Sado, Yoshikazu

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Sugimoto, Manabu

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WEKO 5315

Sugimoto, Manabu

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Kusachi, Shozo

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WEKO 5316

Kusachi, Shozo

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Ninomiya, Yoshifumi

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WEKO 5317

Ninomiya, Yoshifumi

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抄録
内容記述タイプ Abstract
内容記述 The distribution of the collagen chains from α1(IV) to α6(IV) could serve as a basis for the characterization of type IV collagen. In this study, immunohistochemistry of the ocular anterior segment of adult mice was performed using specific monoclonal antibodies against each chain in the series from α1(IV) to α6(IV). The results show that the components of type IV collagen in vascular basement membranes are α1(IV) and α2(IV) with or without α5(IV) and α6(IV) chains and those in epithelium and muscle basement membranes are α1(IV), α2(IV), α5(IV), and α6(IV) chains. In corneal endothelium, pigmented epithelium of iris and ciliary body, and trabecular meshwork, α3(IV) and α4(IV) chains are also expressed in addition to α1(IV), α2(IV), α5(IV), and α6(IV) chains. Moreover, we investigated the change in molecular composition in ciliary body during postnatal development. α3(IV) and α4(IV) chains were also expressed in addition to α1(IV), α2(IV), α5(IV), and α6(IV) chains in ciliary pigmented epithelium basement membrane from 7 days after birth. This result suggests that the basement membranes gradually change their biochemical features owing to temporal regulation. Taken together, these findings suggest that the different distribution and the developmental expression of α1(IV) to α6(IV) chains are associated with the tissue-specific function of type IV collagen in basement membranes.
書誌情報 Connective Tissue Research

巻 52, 号 2, p. 147-156, 発行日 2011-04
ISSN
収録物識別子タイプ ISSN
収録物識別子 0300-8207
DOI
識別子タイプ DOI
関連識別子 10.3109/03008207.2010.492062
出版者
出版者 Informa Healthcare
資源タイプ
内容記述タイプ Other
内容記述 Article
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