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Distribution of α(IV) collagen chains in the ocular anterior segments of adult mice
http://hdl.handle.net/10659/3040
http://hdl.handle.net/10659/3040412b51bd-9964-430c-9ae1-8382fe081d01
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-06-04 | |||||
| タイトル | ||||||
| タイトル | Distribution of α(IV) collagen chains in the ocular anterior segments of adult mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | collagen | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | basement membrane | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | eye | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ciliary body | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | extracellular matrix | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Saito, Kenji
× Saito, Kenji× Yonezawa, Tomoko× MINAGUCHI, Jyun× Kurosaki, Masae× Suetsugu, Shiho× Nakajima, Ai× Nomoto, Hiroyuki× Morizane, Yuki× Sado, Yoshikazu× Sugimoto, Manabu× Kusachi, Shozo× Ninomiya, Yoshifumi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The distribution of the collagen chains from α1(IV) to α6(IV) could serve as a basis for the characterization of type IV collagen. In this study, immunohistochemistry of the ocular anterior segment of adult mice was performed using specific monoclonal antibodies against each chain in the series from α1(IV) to α6(IV). The results show that the components of type IV collagen in vascular basement membranes are α1(IV) and α2(IV) with or without α5(IV) and α6(IV) chains and those in epithelium and muscle basement membranes are α1(IV), α2(IV), α5(IV), and α6(IV) chains. In corneal endothelium, pigmented epithelium of iris and ciliary body, and trabecular meshwork, α3(IV) and α4(IV) chains are also expressed in addition to α1(IV), α2(IV), α5(IV), and α6(IV) chains. Moreover, we investigated the change in molecular composition in ciliary body during postnatal development. α3(IV) and α4(IV) chains were also expressed in addition to α1(IV), α2(IV), α5(IV), and α6(IV) chains in ciliary pigmented epithelium basement membrane from 7 days after birth. This result suggests that the basement membranes gradually change their biochemical features owing to temporal regulation. Taken together, these findings suggest that the different distribution and the developmental expression of α1(IV) to α6(IV) chains are associated with the tissue-specific function of type IV collagen in basement membranes. | |||||
| 書誌情報 |
Connective Tissue Research 巻 52, 号 2, p. 147-156, 発行日 2011-04 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0300-8207 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3109/03008207.2010.492062 | |||||
| 出版者 | ||||||
| 出版者 | Informa Healthcare | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
