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  1. 1:大学
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Effects of NF-κB Expression and Its Inhibition on Canine Mammary Cancer Cell Lines in an Immunodeficient Mice Model

http://hdl.handle.net/10659/3255
http://hdl.handle.net/10659/3255
d731a99e-9878-4e36-9cc2-c7c76ba29279
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-06-04
タイトル
タイトル Effects of NF-κB Expression and Its Inhibition on Canine Mammary Cancer Cell Lines in an Immunodeficient Mice Model
言語
言語 eng
キーワード
主題Scheme Other
主題 canine MGT
キーワード
主題Scheme Other
主題 metastasis
キーワード
主題Scheme Other
主題 molecular targeted therapy
キーワード
主題Scheme Other
主題 NF-κB
キーワード
主題Scheme Other
主題 xenografted model
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 MKAOUAR, Lobna

× MKAOUAR, Lobna

WEKO 5514

MKAOUAR, Lobna

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ENDO, Yoshifumi

× ENDO, Yoshifumi

WEKO 5515
教員総覧 50a71519f7fa9158

ENDO, Yoshifumi

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MOCHIZUKI, Manabu

× MOCHIZUKI, Manabu

WEKO 5516

MOCHIZUKI, Manabu

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NISHIMURA, Ryohei

× NISHIMURA, Ryohei

WEKO 5517

NISHIMURA, Ryohei

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SASAKI, Nobuo

× SASAKI, Nobuo

WEKO 5518

SASAKI, Nobuo

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NAKAGAWA, Takayuki

× NAKAGAWA, Takayuki

WEKO 5519

NAKAGAWA, Takayuki

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抄録
内容記述タイプ Abstract
内容記述 Two canine mammary gland tumor (MGT) cell lines, CHMp-5b and -13a, were transplanted into nude mice, and their tumor development and metastatic potential were evaluated. In addition, NF-κB, Ki-67 and cyclin D1 expressions in the tumor masses were evaluated, and the relationship between these expressions and malignancy of the tumors developed in nude mice was investigated. Lower activation of NF-κB was positively correlated with a lower potential of metastasis and better prognosis in nude mice xenografted with CHMp-13a compared with CHMp-5b. Then, CHMp-5b cells were treated with BAY11-7082, an inhibitor of NF-κB, and the expressions of I-κBα, p-I-κBα, cyclin D1 and Bcl-2 in these cells were evaluated by Western blot analysis. In addition, BAY11-7082 at a dose of 6 mg/kg was administered intraperitoneally to nude mice xenografted with CHMp-5b, and relationships between tumor growth and lung and lymph node metastasis in nude mice and NF-κB, I-κBα and p-I-κBα expressions in tissues of these mice were evaluated. BAY11-7082 treatment induced decreased expressions of p-I-κBα, cyclin D1 and Bcl-2 in a dose- and time-dependent manner, suggesting that BAY inhibited NF-κB in this cell line. CHMp-5b-xenografted mice treated with BAY11-7082 showed a reduction in tumor growth and metastasis. Therefore, inhibition of the NF-κB signaling pathway may be a promising novel therapeutic approach for canine MGTs.
書誌情報 The journal of veterinary medical science

巻 73, 号 12, p. 1539-1546, 発行日 2011-12
DOI
識別子タイプ DOI
関連識別子 10.1292/jvms.10-0580
出版者
出版者 日本獣医学会
資源タイプ
内容記述タイプ Other
内容記述 Article
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