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Local overexpression of interleukin-1 family, member 6 relates to the development of tubulointerstitial lesions
http://hdl.handle.net/10659/2865
http://hdl.handle.net/10659/2865b60fb554-7807-4f5a-a602-78b8ae083515
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
S-2011-145_Endo.pdf (7.8 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2012-10-01 | |||||
| タイトル | ||||||
| タイトル | Local overexpression of interleukin-1 family, member 6 relates to the development of tubulointerstitial lesions | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | biomarker | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | chronic kidney disease | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | collecting duct | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | distal convoluted tubule | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | interleukin-1 family member-6 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | luminal epithelial deciduation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | tubulointerstitial lesion | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Ichii, Osamu
× Ichii, Osamu× Otsuka, Saori× Sasaki, Nobuya× Yabuki, Akira× Ohta, Hiroshi× Takiguchi, Mitsuyoshi× Hashimoto, Yoshiharu× 遠藤, 大二× Kon, Yasuhiro |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Identification of factors that exacerbate a disease is important for the development of biomarkers. In this study, we discovered ectopic overexpression of interleukin-1 family, member-6 (IL-1F6) in several murine renal diseases. IL-1F6 participates in cytokine/chemokine production in the epithelium. In PCR array analysis for inflammatory mediators, Il1f6 showed the highest expression in the kidney of the B6.MRLc1 glomerulonephritis model. IL-1F6 was localized in the epithelium from the DCTs to CCDs, which showed tubular dilations or epithelial deciduations. Ultrastructual examination of the epithelial cells revealed that IL-1F6 was localized on the cytoplasmic ribosome, vesicles, and nucleus. In and around these tubules, we found infiltrations of CD3-positive T-cells and nestin- or α-smooth-muscle actin-positive mesenchymal cells. Expression of the IL-1F6 protein and Il1f6 mRNA in the kidney was increased by the development of TILs in the B6.MRLc1 model and in lupus (BXSB, NZB/WF1, and MRL/lpr), nephrotic syndrome (ICGN), and streptozotocin-induced diabetic models. IL-1F6 was also detected in the epithelia having squamous or deciduous contours in other organs such as the skin, esophagus, thymus, or uterus. In vitro analysis using M-1 cells from the murine collecting duct revealed that Il1f6 mRNA induction was related to the upregulation of IL-6, TGF-β receptor-1, and mesenchymal markers and to the downregulation of epithelial markers and changes in the squamous cells of the epithelium. Interestingly, urine Il1f6 mRNA expression was detected earlier than renal dysfunctions in these mouse models. Ectopic overexpression of IL-1F6 in kidneys is associated with TILs and especially with cell infiltrations and changes in epithelial morphology. We propose that local overexpression of IL-1F6 is related to the development of TILs. | |||||
| 書誌情報 |
Laboratory Investigation 巻 90, 号 3, p. 459-475, 発行日 2010-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0023-6837 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/labinvest.2009.148 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 出版者 | ||||||
| 出版者 | Nature Publishing Group | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
