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Local overexpression of interleukin-1 family, member 6 relates to the development of tubulointerstitial lesions

http://hdl.handle.net/10659/2865
http://hdl.handle.net/10659/2865
b60fb554-7807-4f5a-a602-78b8ae083515
名前 / ファイル ライセンス アクション
S-2011-145_Endo.pdf S-2011-145_Endo.pdf (7.8 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2012-10-01
タイトル
タイトル Local overexpression of interleukin-1 family, member 6 relates to the development of tubulointerstitial lesions
言語
言語 eng
キーワード
主題Scheme Other
主題 biomarker
キーワード
主題Scheme Other
主題 chronic kidney disease
キーワード
主題Scheme Other
主題 collecting duct
キーワード
主題Scheme Other
主題 distal convoluted tubule
キーワード
主題Scheme Other
主題 interleukin-1 family member-6
キーワード
主題Scheme Other
主題 luminal epithelial deciduation
キーワード
主題Scheme Other
主題 tubulointerstitial lesion
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Ichii, Osamu

× Ichii, Osamu

WEKO 6309

Ichii, Osamu

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Otsuka, Saori

× Otsuka, Saori

WEKO 6310

Otsuka, Saori

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Sasaki, Nobuya

× Sasaki, Nobuya

WEKO 6311

Sasaki, Nobuya

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Yabuki, Akira

× Yabuki, Akira

WEKO 6312

Yabuki, Akira

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Ohta, Hiroshi

× Ohta, Hiroshi

WEKO 6313

Ohta, Hiroshi

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Takiguchi, Mitsuyoshi

× Takiguchi, Mitsuyoshi

WEKO 6314

Takiguchi, Mitsuyoshi

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Hashimoto, Yoshiharu

× Hashimoto, Yoshiharu

WEKO 6315

Hashimoto, Yoshiharu

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遠藤, 大二

× 遠藤, 大二

WEKO 4569
教員総覧 9420

en ENDO, Daiji

ja 遠藤, 大二


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Kon, Yasuhiro

× Kon, Yasuhiro

WEKO 6316

Kon, Yasuhiro

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抄録
内容記述タイプ Abstract
内容記述 Identification of factors that exacerbate a disease is important for the development of biomarkers. In this study, we discovered ectopic overexpression of interleukin-1 family, member-6 (IL-1F6) in several murine renal diseases. IL-1F6 participates in cytokine/chemokine production in the epithelium. In PCR array analysis for inflammatory mediators, Il1f6 showed the highest expression in the kidney of the B6.MRLc1 glomerulonephritis model. IL-1F6 was localized in the epithelium from the DCTs to CCDs, which showed tubular dilations or epithelial deciduations. Ultrastructual examination of the epithelial cells revealed that IL-1F6 was localized on the cytoplasmic ribosome, vesicles, and nucleus. In and around these tubules, we found infiltrations of CD3-positive T-cells and nestin- or α-smooth-muscle actin-positive mesenchymal cells. Expression of the IL-1F6 protein and Il1f6 mRNA in the kidney was increased by the development of TILs in the B6.MRLc1 model and in lupus (BXSB, NZB/WF1, and MRL/lpr), nephrotic syndrome (ICGN), and streptozotocin-induced diabetic models. IL-1F6 was also detected in the epithelia having squamous or deciduous contours in other organs such as the skin, esophagus, thymus, or uterus. In vitro analysis using M-1 cells from the murine collecting duct revealed that Il1f6 mRNA induction was related to the upregulation of IL-6, TGF-β receptor-1, and mesenchymal markers and to the downregulation of epithelial markers and changes in the squamous cells of the epithelium. Interestingly, urine Il1f6 mRNA expression was detected earlier than renal dysfunctions in these mouse models. Ectopic overexpression of IL-1F6 in kidneys is associated with TILs and especially with cell infiltrations and changes in epithelial morphology. We propose that local overexpression of IL-1F6 is related to the development of TILs.
書誌情報 Laboratory Investigation

巻 90, 号 3, p. 459-475, 発行日 2010-03
ISSN
収録物識別子タイプ ISSN
収録物識別子 0023-6837
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 10.1038/labinvest.2009.148
著者版フラグ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
出版者
出版者 Nature Publishing Group
資源タイプ
内容記述タイプ Other
内容記述 Article
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