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Onset of autoimmune glomerulonephritis derived from the telomeric region of MRL-chromosome 1 is associated with the male sex hormone in mice
http://hdl.handle.net/10659/1787
http://hdl.handle.net/10659/1787a4f27a4d-0ed6-4d00-9c82-b1259301c9fa
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
S-757_Endoh.pdf (10.8 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-03-31 | |||||
| タイトル | ||||||
| タイトル | Onset of autoimmune glomerulonephritis derived from the telomeric region of MRL-chromosome 1 is associated with the male sex hormone in mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | autoimmune glomerulonephritis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | gonadectomy | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | kidney | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | MRL mouse | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | sex differences | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
ICHII, Osamu
× ICHII, Osamu× KONNO, Akihiro× SASAKI, Nobuya× 遠藤, 大二× HASHIMOTO, Yoshiharu× KON, Yasuhiro |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Female B6.MRLc1(82–100) congenic mice develop more severe autoimmune glomerulonephritis (AGN) than males. We assessed the effects of gonadectomy on the pathogenesis of AGN in these mice. One-month-old male and female mice were divided into sham-operated group (SG) and gonadectomized group (GG), and the pathological changes were investigated at 8 months. SG females showed higher spleen and thymus weights, serum total IgG and autoantibody levels, glomerular damage scores and percent IgG- and CD3-positive glomeruli as compared with SG males. Gonadectomy showed more remarkable effects in males than in females. Spleen and thymus weights, urinary albumin excretion, glomerular damage scores, percent IgG- and CD3-positive glomeruli, and CD3-positive areas in the spleen were significantly higher in GG males than in SG males. CD3-positive cells were observed in both the thymic cortex and medulla in all animals except SG males. The expression ratio of active Fc gamma receptor (Fcgr) 3 to inhibitory Fcgr2b in the kidneys, which we have previously demonstrated to have a great impact on pathogenesis in B6.MRLc1(82–100), was significantly higher in GG males than in SG males. These results suggested that the differences in the pathogenesis of AGN are primarily because of the inhibitory roles of the male sex hormones. | |||||
| 書誌情報 |
Lupus 巻 18, 号 6, p. 491-500, 発行日 2009-05 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0961-2033 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1177/0961203308098989 | |||||
| 権利 | ||||||
| 権利情報 | The final, definitive version of this paper has been published in Lupus, 18(6), 05/2009 by SAGE Publications Ltd, All rights reserved. © SAGE Publications | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 出版者 | ||||||
| 出版者 | SAGE Publications | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
