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Pathological Classification of Canine Mammary Tumor Based on Quantifying mRNA Levels of Hormonal Receptors, SATB1, and Snail in Tissue and Fine Needle Biopsy Samples
http://hdl.handle.net/10659/3456
http://hdl.handle.net/10659/345614076a17-bbfe-4a8f-83d8-30123caf4098
名前 / ファイル | ライセンス | アクション |
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S-2013-120_endo.pdf (1.7 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-06-16 | |||||
タイトル | ||||||
タイトル | Pathological Classification of Canine Mammary Tumor Based on Quantifying mRNA Levels of Hormonal Receptors, SATB1, and Snail in Tissue and Fine Needle Biopsy Samples | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | canine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Fine Needle Biopsy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gene expression | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mammary tumors | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
KOMATSU, Takahiro
× KOMATSU, Takahiro× 岩野, 英知× EBISAWA, Masashi× WATABE, Ai× ENDO, Yoshifumi× HIRAYAMA, Kazuko× TANIYAMA, Hiroyuki× KADOSAWA, Tsuyoshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Cytological diagnosis is not generally conclusive enough to identify histopathological malignancy in canine mammary tumors (CMTs). To establish cytological examination using fine needle biopsy (FNB) samples, gene expressions of hormonal receptors, human epidermal growth factor receptor 2 (HER2), and transcription regulators (Special AT-rich binding protein 1: SATB1 and Snail) were investigated in both tissue and FNB samples of CMTs. In tissue samples of malignant CMTs, especially invasive ones, low expressions of hormonal receptors and high expressions of SATB1 and Snail were detected. On discriminant analysis of tissue samples, 73.2% of CMTs were correctly classified according to histopathological examinations. In FNB samples of malignant CMTs, low expressions of hormonal receptors were detected. On discriminant analysis of FNB samples, 74.2% of CMTs were correctly classified according to histopathological examination. In conclusion, FNB gene expressions had a utility for diagnosis of CMTs malignancy in some degree. By researching more sensitive genes for malignant CMTs, the gene examination of FNB samples from CMTs will become a useful diagnostic tool that can be performed easily without anesthesia and could predict tumor malignancy and invasion prior to surgical removal. | |||||
書誌情報 |
Journal of Veterinary Medical Science 巻 74, 号 6, p. 719-726, 発行日 2012-06 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0916-7250 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1292/jvms.11-0440 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 日本獣医学会 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |