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Pathological correlations between podocyte injuries and renal functions in canine and feline chronic kidney diseases
http://hdl.handle.net/10659/2991
http://hdl.handle.net/10659/29915bf748a9-970e-4e9c-9fc3-f8766664904b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
S-2012-152_endoh.pdf (1.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-06-04 | |||||
| タイトル | ||||||
| タイトル | Pathological correlations between podocyte injuries and renal functions in canine and feline chronic kidney diseases | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CKD | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Podocyte | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Dog | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cat | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Ichii, Osamu
× Ichii, Osamu× Yabuki, Akira× Sasaki, Nobuya× Otsuka, Saori× Ohta, Hiroshi× Yamasaki, Masahiro× Takiguchi, Mitsuyoshi× Namiki, Yuka× Hashimoto, Yoshiharu× 遠藤, 大二× Kon, Yasuhiro |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Podocytes cover the glomerulus and their adjacent foot processes form a principal barrier called the slit diaphragm. Podocyte dysfunctions, including podocyte loss and slit diaphragm disruptions, induce chronic kidney diseases (CKD). In this study, we analyzed the correlations between podocyte injuries and renal dysfunctions in domestic carnivores. Dogs and cats were divided into normal and CKD groups according to renal histopathology and plasma creatinine values. Immunostaining results showed that linear reactions of slit diaphragm molecules, e.g., nephrin, podocin, and ACTN4, were parallel to glomerular capillaries in all animals. However, in dogs, reactions of nephrin and ACTN4 were changed to a granular pattern in the CKD group, and their intensities significantly decreased with the number of podocytes in the glomerulus. Moreover, the expression of nephrin and ACTN4 negatively correlated with creatinine. Real-time PCR analysis showed that nephrin mRNA expression in the kidneys of CKD dogs was significantly lower than that in normal animals, and negatively correlated with creatinine. Although no significant correlation between renal dysfunction and podocyte injury was detected in cats, histoplanimetric scores of tubulointerstitial lesions in CKD cats were higher than those in both normal cats and diseased dogs. Furthermore, mRNAs of WT1 and SD molecules were detected in urine from CKD animals. In conclusion, podocyte injuries such as podocytopenia and decreased expression of nephrin and ACTN4 in the glomerulus were more strongly correlated with renal dysfunction in dogs than in cats. These findings suggest that the CKD pathogenesis, especially susceptibilities to podocyte injuries, differed between dogs and cats. | |||||
| 書誌情報 |
Histology and Histopathology 巻 26, 号 10, p. 1243-1255, 発行日 2011-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0213-3911 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | Universidad de Murcia | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
