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Characterization o fprostanoid receptors present on adrenergic neurons innervating the porcine uterine longitudinal muscle

http://hdl.handle.net/10659/1786
http://hdl.handle.net/10659/1786
bead165f-b836-461b-9fd1-58172df87e0c
名前 / ファイル ライセンス アクション
S-558_Kitazawa.pdf S-558_Kitazawa.pdf (863.3 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2011-03-31
タイトル
タイトル Characterization o fprostanoid receptors present on adrenergic neurons innervating the porcine uterine longitudinal muscle
言語
言語 eng
キーワード
主題Scheme Other
主題 Porcine uterus
キーワード
主題Scheme Other
主題 Prostanoids
キーワード
主題Scheme Other
主題 Prostanoid receptor
キーワード
主題Scheme Other
主題 Adrenergic neurons
キーワード
主題Scheme Other
主題 Noradrenaline release
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Cao, Jinshan

× Cao, Jinshan

WEKO 9267

Cao, Jinshan

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Nakamura, Tatsuro

× Nakamura, Tatsuro

WEKO 9268

Nakamura, Tatsuro

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Kitazawa, Takio

× Kitazawa, Takio

WEKO 9269

Kitazawa, Takio

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Yamashiki, Naoko

× Yamashiki, Naoko

WEKO 9270

Yamashiki, Naoko

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Yamamoto, Tsubasa

× Yamamoto, Tsubasa

WEKO 9271

Yamamoto, Tsubasa

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Taneike, Tetsuro

× Taneike, Tetsuro

WEKO 9272

Taneike, Tetsuro

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抄録
内容記述タイプ Abstract
内容記述 The cyclooxygenase-prostanoid pathway regulates myometrial contractility through activation of prostanoid receptors on uterine smooth muscles. However, the possible expression of prostanoid receptors on autonomic nerves cannot be excluded completely. The aim of the present study was to clarify the presence of neural prostanoid receptors on adrenergic nerves in the porcine uterine longitudinal muscle. In [^3H]-noradrenaline-loaded longitudinal muscle strips of porcine uterus, electrical field stimulation (EFS) evoked [^3H]-noradrenaline release in a stimulation frequency-dependent manner. The EFS-evoked release was completely abolished in Ca^<2+>-free (EGTA, 1 mM) incubation medium and by tetrodotoxin or ω-conotoxin GVIA, suggesting that [^3H]-noradrenaline was released from neural components. The EFS-evoked [^3H]-noradrenaline release was significantly enhanced by treatment with indomethacin. In the presence of indomethacin, PGE_2 and PGF_<2α>, but not PGD2, inhibited the EFS-evoked [^3H]-noradrenaline release. Of synthetic prostanoid receptor agonists examined, both U46619 (TP) and sulprostone (EP_1/EP_3) decreased the EFS-evoked [^3H]-noradrenaline release in a concentration-dependent manner, while fluprostenol (FP), BW245C (DP) and butaprost (EP_2) were almost ineffective. SQ29548 (TP receptor antagonist) blocked the effect of U46619, but SC19220 (EP_1 receptor antagonist) did not change the inhibition by sulprostone or PGE_2. Double immunofluorescence staining using protein gene product 9.5, tyrosine hydroxylase, EP_3 receptor and TP receptor antibodies suggested the localization of EP_3 or TP receptors on adrenergic nerves in the porcine uterus. These results indicated that neural EP_3 and TP receptors are present on adrenergic nerves of the porcine uterine longitudinal muscle. Endogenous prostanoid produced by cyclooxygenase can regulate noradrenaline release in an inhibitory manner through activation of these neural prostanoid receptors.
書誌情報 Prostaglandins & other lipid mediators

巻 86, 号 1-4, p. 26-34, 発行日 2008-06
ISSN
収録物識別子タイプ ISSN
収録物識別子 1098-8823
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 10.1016/j.prostaglandins.2008.02.002
権利(URI)
権利情報 http://dx.doi.org/10.1016/j.prostaglandins.2008.02.002 | http://dx.doi.org/10.1016/j.prostaglandins.2008.02.002
著者版フラグ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
出版者
出版者 Elsevier
資源タイプ
内容記述タイプ Other
内容記述 Article
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