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In situ hybridization study of CYP2D mRNA in the common marmoset brain
http://hdl.handle.net/10659/00005381
http://hdl.handle.net/10659/0000538169c18fff-79ec-4262-bc13-7a776cb96e32
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
R-2017-43_Tsubakishita.pdf (3.5 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-04-12 | |||||
| タイトル | ||||||
| タイトル | In situ hybridization study of CYP2D mRNA in the common marmoset brain | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | brain | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | chromosome | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | common marmoset | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CYP2D | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | in situ hybridization | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Shimamoto, Yoshinori
× Shimamoto, Yoshinori× Niimi, Kimie× 北村, 浩× 椿下, 早絵× Takahashi, Eiki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The common marmoset is a non-human primate that has increasingly employed in the biomedical research including the fields of neuroscience and behavioral studies. Cytochrome P450 (CYP) 2D has been speculated to be involved in psycho-neurologic actions in the human brain. In the present study, to clarify the role of CYP2D in the marmoset brain, we investigated the expression patterns of CYP2D mRNA in the brain using in situ hybridization (ISH). In addition, to identify the gene location of CYP2D19, a well-studied CYP2D isoform in the common marmoset, a fluorescence in situ hybridization (FISH) study was performed. Consistent with findings for the human brain, CYP2D mRNA was localized in the neuronal cells of different brain regions; e.g., the cerebral cortex, hippocampus, substantia nigra, and cerebellum. FISH analysis showed that the CYP2D19 gene was located on chromosome 1q, which is homologous to human chromosome 22 on which the CYP2D6 gene exists. These results suggest that CYP2D in the marmoset brain may play the same role as human CYP2D6 in terms of brain actions, and that the CYP2D19 gene is conserved in a syntenic manner. Taken together, these findings suggest that the common marmoset is a useful model for studying psychiatric disorders related to CYP2D dysfunction in the brain. | |||||
| 書誌情報 |
Experimental Animals 巻 65, 号 4, p. 465-471, 発行日 2016-11 |
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| ISBN | ||||||
| 識別子タイプ | ISBN | |||||
| 関連識別子 | 1341-1357 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.1538/expanim.16-0045 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 日本実験動物学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
