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Phenotypic and molecular characterization of antimicrobial resistance in Enterobacter spp. isolates from companion animals in Japan

http://hdl.handle.net/10659/00005885
http://hdl.handle.net/10659/00005885
a80cb965-da69-483a-8214-b571b3d1f7ba
名前 / ファイル ライセンス アクション
R-2018-34_usui.pdf R-2018-34_usui.pdf (1.1 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-08-08
タイトル
タイトル Phenotypic and molecular characterization of antimicrobial resistance in Enterobacter spp. isolates from companion animals in Japan
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Harada, Kazuki

× Harada, Kazuki

WEKO 17791

Harada, Kazuki

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Shimizu, Takae

× Shimizu, Takae

WEKO 17792

Shimizu, Takae

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Mukai, Yujiro

× Mukai, Yujiro

WEKO 17793

Mukai, Yujiro

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Kuwajima, Ken

× Kuwajima, Ken

WEKO 17794

Kuwajima, Ken

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Sato, Tomomi

× Sato, Tomomi

WEKO 17795

Sato, Tomomi

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Kajino, Akari

× Kajino, Akari

WEKO 17796

Kajino, Akari

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臼井, 優

× 臼井, 優

WEKO 4683
教員総覧 9437

en USUI, Masaru

ja 臼井, 優


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Tamura, Yutaka

× Tamura, Yutaka

WEKO 4684
教員総覧 bd945a92d328be7d78b5914b856835a6

Tamura, Yutaka

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Kimura, Yui

× Kimura, Yui

WEKO 17797

Kimura, Yui

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Miyamoto, Tadashi

× Miyamoto, Tadashi

WEKO 17798

Miyamoto, Tadashi

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Tsuyuki, Yuzo

× Tsuyuki, Yuzo

WEKO 17799

Tsuyuki, Yuzo

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Ohki, Asami

× Ohki, Asami

WEKO 17800

Ohki, Asami

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Kataoka, Yasushi

× Kataoka, Yasushi

WEKO 17801

Kataoka, Yasushi

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抄録
内容記述タイプ Abstract
内容記述 The emergence of antimicrobial resistance among Enterobacter spp., including resistance to extended-spectrum cephalosporins (ESC), is of great concern in both human and veterinary medicine. In this study, we investigated the prevalence of antimicrobial resistance among 60 isolates of Enterobacter spp., including E. cloacae (n = 44), E. aerogenes (n = 10), and E. asburiae (n = 6), from clinical specimens of dogs and cats from 15 prefectures in Japan. Furthermore, we characterized the resistance mechanisms harbored by these isolates, including extended-spectrum β-lactamases (ESBLs) and plasmid-mediated quinolone resistance (PMQR); and assessed the genetic relatedness of ESC-resistant Enterobacter spp. strains by multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE). Antimicrobial susceptibility testing demonstrated the resistance rates to ampicillin (93.3%), amoxicillin-clavulanic acid (93.3%), cefmetazole (93.3%), chloramphenicol (46.7%), ciprofloxacin (43.3%), tetracycline (40.0%), ceftazidime (33.3%), cefotaxime (33.3%), trimethoprim/sulfamethoxazole (28.3%), gentamicin (23.3%), and meropenem (0%). Phenotypic testing detected ESBLs in 16 of 18 ESC-resistant E. cloacae isolates but not in the other species. The most frequent ESBL was CTX-M-15 (n = 8), followed by SHV-12 (n = 7), and CTX-M-3 (n = 1). As for AmpC β-lactamases, CMY-2 (n = 2) and DHA-1 (n = 2) were identified in ESC-resistant E. cloacae strains with or without ESBLs. All of the ESC-resistant E. cloacae strains also harbored one or two PMQRs, including qnrB (n = 15), aac(6’)-Ib-cr (n = 8), and qnrS (n = 2). Based on MLST and PFGE analysis, E. cloacae clones of ST591-SHV-12, ST171-CTX-M-15, and ST121-CTX-M-15 were detected in one or several hospitals. These results suggested intra- and inter-hospital dissemination of E. cloacae clones co-harboring ESBLs and PMQRs among companion animals. This is the first report on the large-scale monitoring of antimicrobial-resistant isolates of Enterobacter spp. from companion animals in Japan.
書誌情報 PLOS ONE

巻 12, 号 3, p. e0174178-1-e0174178-12, 発行日 2017-03
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1371/journal.pone.0174178
権利
権利情報 © 2017 Harada et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
権利(URI)
権利情報 http://creativecommons.org/licenses/by/4.0/ | http://creativecommons.org/licenses/by/4.0/
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
出版者
出版者 PLOS
資源タイプ
内容記述タイプ Other
内容記述 Article
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