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Collagen peptide ingestion alters lipid metabolism-related gene expression and the unfolded protein response in mouse liver
http://hdl.handle.net/10659/00005896
http://hdl.handle.net/10659/00005896199ef585-ad7e-4770-aa50-307192de85a6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
R-2018-82_takehana.pdf (697.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2019-08-08 | |||||
| タイトル | ||||||
| タイトル | Collagen peptide ingestion alters lipid metabolism-related gene expression and the unfolded protein response in mouse liver | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Collagen peptide | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Liver | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Lipid metabolism | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Unfolded protein response | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | DNA microarray | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Collagen peptide | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Liver | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Lipid metabolism | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Unfolded protein response | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | DNA microarray | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Tometsuka, Chisa
× Tometsuka, Chisa× Koyama, Yoh-ichi× Ishijima, Tomoko× Toyoda, Tsudoi× Teranishi, Miki× Takehana, Kazushige× Abe, Keiko× Nakai, Yuji |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Ingestion of collagen peptide (CP) elicits beneficial effects on the body, including improvement in blood lipid profiles, but the underlying mechanisms remain unclear. The purpose of this study was to investigate the effects of CP ingestion on the liver, which controls lipid metabolism in the body. Male BALB/cCrSlc mice were bred with the AIN-93M diet containing 14 % casein or the AIN-93M-based low-protein diet containing 10 % casein or a diet containing 6 % casein+4 % CP for 10 weeks (n 12/group). Total, free and esterified cholesterol levels in the blood decreased in the CP group. DNA microarray analysis of the liver revealed that expressions of genes related to lipid metabolic processes such as the PPAR signalling pathway and fatty acid metabolism increased in the CP group compared with the 10 % casein group. The expressions of several genes involved in steroid metabolic process, including Cyp7a1 and Cyp8b1, were decreased, despite being targets of transcriptional regulation by PPAR. These data suggest that lipid metabolism in the liver is altered by CP ingestion, and the decrease in blood cholesterol levels in the CP group is not due to enhancement of the steroid metabolic process. On the other hand, expressions of genes related to the unfolded protein response (UPR) significantly decreased at the mRNA level, suggesting that CP ingestion lowers endoplasmic reticulum stress. Indeed, protein levels of phosphorylated inositol-requiring enzyme 1 decreased after CP ingestion. Taken together, CP affects the broader pathways in the liver – not only lipid metabolism but also UPR. | |||||
| 書誌情報 |
British Journal of Nutrition 巻 117, 号 1, p. 1-11, 発行日 2017-01 |
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| ISBN | ||||||
| 識別子タイプ | ISBN | |||||
| 関連識別子 | 0007-1145 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1017/S0007114516004384 | |||||
| 権利 | ||||||
| 権利情報 | © The Authors 2017 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | Cambridge University Press | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
