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Morphometric analysis of cornea in the Slc39a13/Zip13-knockout mice
http://hdl.handle.net/10659/00006312
http://hdl.handle.net/10659/0000631295ce59cf-0de6-42c4-b40f-738668f809b6
名前 / ファイル | ライセンス | アクション |
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R-2019-61_takehana.pdf (2.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-02-26 | |||||
タイトル | ||||||
タイトル | Morphometric analysis of cornea in the Slc39a13/Zip13-knockout mice | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | collagen fibril | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cornea | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | morphometry | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Slc39a13/Zip13-knockout mice | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | collagen fibril | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | cornea | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | morphometry | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Slc39a13/Zip13-knockout mice | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
HIROSE, Takuya
× HIROSE, Takuya× SUZUKI, Ippei× TAKAHASHI, Naoki× FUKADA, Toshiyuki× TANGKAWATTANA, Prasarn× TAKEHANA, Kazushige |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Ehlers-Danlos syndrome (EDS) is a group of hereditary diseases caused by mutation of extracellular matrix-related genes. Recently, spondylodysplastic EDS-Zip13 (spEDS-Zip13: OMIM 612350) was recognized as a new EDS type. This current study could reveal various morphometric differences of collagenous population in the proper substance of cornea between the wild type and spEDS-Zip13-knockout (Zip13-KO) mice. Blockade of Smad-signaling pathway might initiate these alterations. Predilected dissimilarity in level of transcriptional activity probably dictated morphology of keratocyte and shape and electron density of its nucleus. In addition, the imbalance of proteoglycans and glycosaminoglycans would also affect the diameter and arrangement of collagen fibrils. These findings would be considered as vulnerable characteristics of corneal stroma of the Zip13-KO mice. | |||||
書誌情報 |
Journal of Veterinary Medical Science 巻 80, 号 5, p. 814-818, 発行日 2018-05 |
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ISBN | ||||||
識別子タイプ | ISBN | |||||
関連識別子 | 0916-7250 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1292/jvms.18-0019 | |||||
権利 | ||||||
権利情報 | © 2018 The Japanese Society of Veterinary Science | |||||
権利(URI) | ||||||
権利情報 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 日本獣医学会 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |