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Aflatoxin Exposure from Milk in Rural Kenya and the Contribution to the Risk of Liver Cancer
http://hdl.handle.net/10659/00006637
http://hdl.handle.net/10659/00006637d1d71ac9-a776-4a4e-938d-b5c62724d459
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
R-2020-63_makita.pdf (957.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-11-18 | |||||
| タイトル | ||||||
| タイトル | Aflatoxin Exposure from Milk in Rural Kenya and the Contribution to the Risk of Liver Cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mycotoxins | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | risk assessment | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | food safety standards | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hepatocellular carcinoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | East Africa | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | mycotoxins | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | risk assessment | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | food safety standards | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | hepatocellular carcinoma | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | East Africa | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Sirma, Anima J.
× Sirma, Anima J.× 蒔田, 浩平× Randolph, Delia Grace× Senerwa, Daniel× Lindahl, Johanna F. |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Milk is an important commodity in Kenya; the country has the largest dairy herd and highest per capita milk consumption in East Africa. As such, hazards in milk are of concern. Aflatoxin M1 (AFM1) is a toxic metabolite of aflatoxin B1 (AFB1) excreted in milk by lactating animals after ingesting AFB1-contaminated feeds. This metabolite is injurious to human health, but there is little information on the risk to human health posed by AFM1 in milk in rural Kenya. To fill this gap, a quantitative risk assessment (QRA) applying probabilistic statistical tools to quantify risks was conducted. This assessed the risk of liver cancer posed by AFM1 in milk, assuming 10-fold lower carcinogenicity than AFB1. Data from four agro–ecological zones in Kenya (semi-arid, temperate, sub-humid and humid) were used. We estimated that people were exposed to between 0.3 and 1 ng AFM1 per kg body weight per day through the consumption of milk. The annual incidence rates of cancer attributed to the consumption of AFM1 in milk were 3.5 × 10−3 (95% CI: 3 × 10−3–3.9 × 10−3), 2.9 × 10−3 (95% CI: 2.5 × 10−3–3.3 × 10−3), 1.4 × 10−3 (95% CI: 1.2 × 10−3–1.5 × 10−3) and 2.7 × 10−3 (95% CI: 2.3 × 10−3–3 × 10−3) cancers per 100,000 in adult females, adult males, children 6–18 years old, and in children less than five years old, respectively. Our results show that aflatoxin exposure from milk contributes relatively little to the incidence of liver cancer. Nonetheless, risk managers should take action based on cumulative exposure from all sources of aflatoxins. | |||||
| 書誌情報 |
Toxins 巻 11, 号 8, p. 469-1-469-12, 発行日 2019-08 |
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| ISBN | ||||||
| 識別子タイプ | ISBN | |||||
| 関連識別子 | 2072-6651 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.3390/toxins11080469 | |||||
| 権利（URI） | ||||||
| 権利情報 | https://creativecommons.org/licenses/by/4.0/ | https://creativecommons.org/licenses/by/4.0/ | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | MDPI AG | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
