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Carboxylic Acids with Certain Molecular Structures Decrease Osmotic Fragility against Osmotic Pressure in Cattle Erythrocytes In Vitro : Appearance of a Wedge-like Effect Similar to RBCs in Other Animal Species
http://hdl.handle.net/10659/00006645
http://hdl.handle.net/10659/00006645a67d984a-9b0f-4902-84b6-01e9b5d336f3
名前 / ファイル | ライセンス | アクション |
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R-2020-101_moriyoshi.pdf (822.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-11-18 | |||||
タイトル | ||||||
タイトル | Carboxylic Acids with Certain Molecular Structures Decrease Osmotic Fragility against Osmotic Pressure in Cattle Erythrocytes In Vitro : Appearance of a Wedge-like Effect Similar to RBCs in Other Animal Species | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Carboxylic acid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Erythrocyte | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Osmotic fragility | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Membrane | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Phospholipid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Arachidonic acid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Partition coefficient | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cattle | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Wedge-like effect | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Carboxylic acid | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Erythrocyte | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Osmotic fragility | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Membrane | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Phospholipid | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Arachidonic acid | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Partition coefficient | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Cattle | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Wedge-like effect | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Mineo, Hitoshi
× Mineo, Hitoshi× Moriyoshi, Masaharu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Osmotic fragility (OF) in red blood cells (RBCs) is a useful tool for evaluating the actions of various chemicals on the cell membrane in vitro. The effects of monocarboxylic and dicarboxylic acids on OF were evaluated in cattle RBCs. Isolated cattle RBCs were immersed in various carboxylic acids at 0-100 mM in a buffer solution for 1 hr and the 50% hemolysis was then determined by soaking in 0.1-0.8% NaCl solution. Although n-caprylic acid at 100 mM induced hemolysis, the other monocarboxylic acids possessing straight hydrocarbons did not affect OF. The dicarboxylic acids possessing straight hydrocarbons, except for glutaric acid, decreased OF in a dose-dependent manner. Some monocarboxylic acids with branched hydrocarbons tended to decrease OF, but these changes were not statistically significant. Although cyclopentanecarboxylic and cyclohexanecarboxylic acids at 100 mM decreased OF, other monocarboxylic acids with cyclic hydrocarbons did not affect OF. Among the dicarboxylic acids with cyclic hydrocarbons tested, only 1,2-cyclohexanedicarboxylic acid and phthalic acid with a benzene ring significantly decreased OF. There is no clear correlation between the effect of monocarboxylic or dicarboxylic acids on OF, and their partition coefficients. Thus, the partition coefficient is not a suitable parameter for explaining the effect of both groups of carboxylic acids on OF in cattle RBCs. With regard to the effect of monocarboxylic acids on OF, although an increase in OF was demonstrated in rat RBCs, no effect or rather a decrease in OF was demonstrated in cattle RBCs, similar to the results observed for guinea pig and sheep RBCs. With regard to the effect of dicarboxylic acids, decreases in OF were already demonstrated in rat, guinea pig and sheep RBCs. We have proposed that dicarboxylic acids exhibit a common stabilizing effect on the RBC membrane in various animals, which we termed a “wedge-like effect”. We clarified that cattle RBCs also show a similar OF response to dicarboxylic acids in this experiment. | |||||
書誌情報 |
Biochemistry & Pharmacology : Open Access 巻 8, 号 1, p. 264-1-264-12, 発行日 2019-03 |
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ISBN | ||||||
識別子タイプ | ISBN | |||||
関連識別子 | 2167-0501 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | http://dx.doi.org/10.35248/2167-0501.19.8.264 | |||||
権利 | ||||||
権利情報 | © 2019 Mineo H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Longdom Publishing | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |