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Genetic diversity of cytochrome P450 1A2 with different metabolic activities in domestic cats
http://hdl.handle.net/10659/00006656
http://hdl.handle.net/10659/00006656514eeac7-938e-4e59-bba8-ae7baadd6ad4
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
R-2020-171_teraoka.pdf (732.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-11-18 | |||||
| タイトル | ||||||
| タイトル | Genetic diversity of cytochrome P450 1A2 with different metabolic activities in domestic cats | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cytochrome P450 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | domestic cat | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | polymorphism | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | xenobiotic | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | cytochrome P450 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | domestic cat | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | polymorphism | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | xenobiotic | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
SUGIYAMA, Souta
× SUGIYAMA, Souta× UNO, Yasuhiro× 天野, 朋子× KITAZAWA, Takio× TERAOKA, Hiroki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Knowledge of genetic polymorphisms of metabolizing enzymes of medical drugs and xenobiotics including cytochrome P450 (CYP) is very limited in cats. We investigated polymorphisms in CYP1A2, one of the major CYP isoforms in the feline liver. Wild-type and three non-synonymous polymorphic variants, but no synonymous variant, were identified in feline CYP1A2 in 50 alleles of domestic cats in Japan. Metabolic parameters, Km and Vmax, of ethoxyresorufin hydroxylation by CYP1A2 were shown to range within two times for identified non-synonymous variants by using a heterologous coexpression system. The results confirmed the polymorphic nature of CYP1A2 as a basis for effective application of medicines and prevention of adverse reactions in the treatment of domestic cats as well as for hereditary disorders. | |||||
| 書誌情報 |
Journal of Veterinary Medical Science 巻 81, 号 7, p. 980-982, 発行日 2019-07 |
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| ISBN | ||||||
| 識別子タイプ | ISBN | |||||
| 関連識別子 | 0916-7250 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1292/jvms.19-0106 | |||||
| 権利（URI） | ||||||
| 権利情報 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 日本獣医学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
