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The Suppression of Th1 Response by Inducing TGF-β1 From Regulatory T Cells in Bovine Mycoplasmosis
http://hdl.handle.net/10659/00006985
http://hdl.handle.net/10659/00006985fa9f0073-f48b-428d-ab05-4202c7cf934b
名前 / ファイル | ライセンス | アクション |
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R-2021-24_higuchi.pdf (1.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-02-21 | |||||
タイトル | ||||||
タイトル | The Suppression of Th1 Response by Inducing TGF-β1 From Regulatory T Cells in Bovine Mycoplasmosis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TGF-b1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mycoplasma bovis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | regulatory T cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | immunosuppression | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cattle | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | TGF-b1 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Mycoplasma bovis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | regulatory T cell | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | immunosuppression | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | cattle | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Sajiki, Yamato
× Sajiki, Yamato× Konnai, Satoru× Goto, Shinya× Okagawa, Tomohiro× Ohira, Kosuke× Shimakura, Honami× Maekawa, Naoya× 権平, 智× 樋口, 豪紀× 田島, 誉士× Hirano, Yuki× Kohara, Junko× Murata, Shiro× Ohashi, Kazuhiko |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Regulatory T cells (Tregs) regulate immune responses and maintain host immune homeostasis. Tregs contribute to the disease progression of several chronic infections by oversuppressing immune responses via the secretion of immunosuppressive cytokines, such as transforming growth factor (TGF)-β and interleukin-10. In the present study, we examined the association of Tregs with Mycoplasma bovis infection, in which immunosuppression is frequently observed. Compared with uninfected cattle, the percentage of Tregs, CD4+CD25highFoxp3+ T cells, was increased in M. bovis-infected cattle. Additionally, the plasma of M. bovis-infected cattle contained the high concentrations of TGF-β1, and M. bovis infection induced TGF-β1 production from bovine immune cells in in vitro cultures. Finally, we analyzed the immunosuppressive effects of TGF-β1 on bovine immune cells. Treatment with TGF-β1 significantly decreased the expression of CD69, an activation marker, in T cells, and Th1 cytokine production in vitro. These results suggest that the increase in Tregs and TGF-β1 secretion could be one of the immunosuppressive mechanisms and that lead to increased susceptibility to other infections in terms of exacerbation of disease during M. bovis infection. | |||||
書誌情報 |
Frontiers in Veterinary Science 巻 7, p. 609443-1-609443-9, 発行日 2020-12 |
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DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.3389/fvets.2020.609443 | |||||
権利(URI) | ||||||
権利情報 | http://creativecommons.org/licenses/by/4.0/ | http://creativecommons.org/licenses/by/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Frontiers Media SA | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |