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Altered balance of inhibitory and active Fc gamma receptors in murine autoimmune glomerulonephritis
http://hdl.handle.net/10659/2310
http://hdl.handle.net/10659/231094aa7ef3-2908-4674-b5f5-a4b7b8f497af
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
S-550_Endoh.pdf (6.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2011-06-14 | |||||
| タイトル | ||||||
| タイトル | Altered balance of inhibitory and active Fc gamma receptors in murine autoimmune glomerulonephritis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | autoimmunity | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Fc gamma receptor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | glomerulonephritis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | kidney | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | MRL mice | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Ichii, Osamu
× Ichii, Osamu× Konno, Akihiro× Sasaki, Nobuya× 遠藤, 大二× Hashimoto, Yoshiharu× Kon, Yasuhiro |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Mag is an MRL-derived glomerulonephritis susceptibility locus that includes the Fcgr2b and Fcgr3 genes encoding the inhibitory Fc gamma receptor IIB (FcγRIIB) and active FcγRIII, respectively. We measured changes in gene balance in three B6.MRLc1 congenic mouse strains containing the 82-86, 92–100 and 100 cM regions of the MRL chromosome 1. We found that only the strain that has 92-100 (which includes Fcgr loci) developed glomerulonephritis. These congenic mice had splenomegaly, elevated blood urea nitrogen, anti-dsDNA antibodies and higher urinary albumin excretion compared to the parental strain C57BL/6(B6). Prior to the development of glomerulonephritis, large CD3- (T cell) and B220- (B cell) positive areas were identified in the spleens of B6.MRLc1(92–100) mice. Both Fc receptors were found in mesangial and dendritic cells; important sites of immune-complex clearance and antigen presentation. The FcγRIII-positive areas were more prominent in the congenic strain. Fcgr2b mRNA was lower in the B6.MRLc1(92–100) kidney and spleen than in those organs of the B6 mice while Fcgr3 expression and the Fcgr3 to Fcgr2b mRNA ratio was higher in the congenic strain kidneys, spleen and thymus than in those of the B6 prior to and at an early stage of glomerulonephritis. We conclude that the imbalance of inhibitory and active Fc gamma receptors influences the pathogenesis of glomerulonephritis. | |||||
| 書誌情報 |
Kidney international 巻 74, 号 3, p. 339-347, 発行日 2008-08 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0085-2538 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/ki.2008.182 | |||||
| 権利 | ||||||
| 権利情報 | http://dx.doi.org/10.1038/ki.2008.182 | |||||
| 権利（URI） | ||||||
| 権利情報 | http://creativecommons.org/licenses/by-nc-sa/3.0/ | http://creativecommons.org/licenses/by-nc-sa/3.0/ | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | Nature publishing group | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
