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Effects of a Single Bolus Intravenous Dose of Tramadol on Minimum Alveolar Concentration (MAC) of Sevoflurane in Dogs
http://hdl.handle.net/10659/3812
http://hdl.handle.net/10659/3812036fd439-8599-4af8-9324-c7cdd4ff5616
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
S-2014-168_miyoshi.pdf (579.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-05-12 | |||||
| タイトル | ||||||
| タイトル | Effects of a Single Bolus Intravenous Dose of Tramadol on Minimum Alveolar Concentration (MAC) of Sevoflurane in Dogs | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | canine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | minimum alveolar concentration (MAC) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | O-desmethyltramadol (M1) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | sevoflurane | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | tramadol | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
ITAMI, Takaharu
× ITAMI, Takaharu× KAWASE, Kodai× TAMARU, Naomichi× ISHIZUKA, Tomohito× TAMURA, Jun× 三好, 健二郎× UMAR, Mohammed A.× INOUE, Hiroki× 山下, 和人 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Tramadol is an atypical opioid analgesic widely used in small animal practice. This study was designed to determine the effect of a single intravenous (IV) dose of tramadol on the minimum alveolar concentration (MAC) of sevoflurane in dogs. Six beagle dogs were anesthetized twice to determine the sevoflurane MAC with or without an administration of tramadol (4mg/kg, IV) at 7 days interval. The sevoflurane MAC was determined using a tail clamp method in each dog ventilated with positive pressure ventilation. The tramadol administration produced a significant reduction in the sevoflurane MAC by 22.3±12.2% (1.44±0.28% with tramadol versus 1.86±0.30% without tramadol, P=0.010). This MAC reduction had been determined from 122±19 to 180±41 min following the tramadol administration. During this period, the plasma concentrations of tramadol and its metabolite, O-desmethyltramadol (M1), decreased from 429±64 to 332±55 ng/ml and from 136±24 to 114±68 ng/ml, respectively, but these changes were not statistically significant. There was no significant difference in heart rate, mean arterial blood pressure and SpO_2 between the control and tramadol treatment. The dogs that received tramadol treatment sometimes breathed spontaneously. Therefore, their respiratory rates significantly increased, and PETCO_2 decreased during the MAC determination. In conclusion, the single IV dose of tramadol produced a significant reduction in the sevoflurane MAC in dogs. | |||||
| 書誌情報 |
Journal of Veterinary Medical Science 巻 75, 号 5, p. 613-618, 発行日 2013-05 |
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| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1292/jvms.12-0208 | |||||
| 権利 | ||||||
| 権利情報 | ©2013 The Japanese Society of Veterinary Science | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 日本獣医学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
