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Genetic background-dependent diversity in renal failure caused by the tensin2 gene deficiency in the mouse
http://hdl.handle.net/10659/4992
http://hdl.handle.net/10659/49928a9a4239-6507-4d93-8eb3-179920b47d24
名前 / ファイル | ライセンス | アクション |
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S-2016-148_kitamura.pdf (2.8 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-06-09 | |||||
タイトル | ||||||
タイトル | Genetic background-dependent diversity in renal failure caused by the tensin2 gene deficiency in the mouse | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
SASAKI, Hayato
× SASAKI, Hayato× MARUSUGI, Kiyoma× KIMURA, Junpei× 北村, 浩× NAGASAKI, Ken-Ichi× TORIGOE, Daisuke× AGUI, Takashi× SASAKI, Nobuya |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Tensin2 (Tns2) is thought to be a component of the cytoskeletal structures linking actin filaments with focal adhesions and is known to play a role as an intracellular signal transduction mediator through integrin in podocytes, although the mechanism by which it functions remains unclear. A Tns2-null mutation (nph) leads to massive albuminuria following podocyte foot process effacement in the ICGN mice, the origin of the mutation, and the DBA/2J (D2) mice, but not in the C57BL/6J (B6) mice or 129^<+Ter>/SvJcl (129T) mice. Elucidating the reasons for these differences in diverse genetic backgrounds could help in unraveling Tns2 function in podocytes. We produced congenic mice in which Tns2^<nph> was introgressed into a FVB/NJ background (FVB-Tns2^<nph>), and evaluated the progression of kidney disease. FVB-Tns2^<nph> mice developed albuminuria, renal fibrosis and renal anemia as seen in ICGN mice. The FVB-Tns2nph mice demonstrated podocyte foot process alteration under an electron microscope by as early as 4 weeks of age. This revealed that FVB strain is susceptible to Tns2-deficiency. | |||||
書誌情報 |
Biomedical Research 巻 36, 号 5, p. 323-330, 発行日 2015-10 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1880-313X | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2220/biomedres.36.323 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Biomedical Research | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |