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Genetic relatedness between Japanese and European isolates of Clostridium difficile originating from piglets and their risk associated with human health
http://hdl.handle.net/10659/4292
http://hdl.handle.net/10659/429222e51c30-0019-43ea-97ed-2e92db3efb75
名前 / ファイル | ライセンス | アクション |
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S-2015-177_tamura.pdf (2.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2016-05-23 | |||||
タイトル | ||||||
タイトル | Genetic relatedness between Japanese and European isolates of Clostridium difficile originating from piglets and their risk associated with human health | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antimicrobial resistance | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Clostridium difficile | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MLVA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PCR ribotype 078 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | piglets | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Usui, Masaru
× Usui, Masaru× Nanbu, Yukie× Oka, Kentaro× Takahashi, Motomichi× Inamatsu, Takashi× Asai, Tetsuo× Kamiya, Shigeru× Tamura, Yutaka |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Clostridium difficile colonization in pig intestine has been a public health concern. We analyzed C. difficile prevalence among piglets in Japan to clarify their origin and extent of the associated risk by using molecular and microbiological methods for both swine and human clinical isolates and foreign isolates. C. difficile was isolated from 120 neonatal piglet fecal samples. Toxin gene profile, antimicrobial susceptibilities, PCR ribotype, and multiple-locus variable-number tandem-repeat analysis (MLVA) type of swine isolates were determined and compared with those of human clinical and foreign isolates. One-hundred C. difficile strains were isolated from 69 (57.5%) samples, and 61 isolates (61%) were toxin gene-positive. Some isolates were resistant to antimicrobials, contributing to antibiotic-associated diarrhea by C. difficile. These results suggest that C. difficile, prevalent among Japanese pigs, is a potential risk for antibiotic-associated diarrhea. Furthermore, PCR ribotype 078 (12 isolates), which has been linked to multiple outbreaks worldwide, was the third-most frequently isolated of the 14 PCR ribotypes identified. Moreover, MLVA revealed that all 12 PCR ribotype 078 isolates were genetically related to European PCR ribotype 078 strains found in both humans and pigs. To date, in Japan, many breeding pigs have been imported from European countries. The genetic relatedness of C. difficile isolates of Japanese swine origin to those of European origin suggests that they were introduced into Japan via imported pigs. | |||||
書誌情報 |
Frontiers in Microbiology 巻 5, p. 513-1-513-8, 発行日 2014-10 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1664-302X | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3389/fmicb.2014.00513 | |||||
権利 | ||||||
権利情報 | © 2014 Usui, Nanbu, Oka, Takahashi, Inamatsu, Asai, Kamiya and Tamura. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). | |||||
権利(URI) | ||||||
権利情報 | http://creativecommons.org/licenses/by/4.0/ | http://creativecommons.org/licenses/by/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Frontiers Media S.A. | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |