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Histological and Immunohistochemical Evaluations of Lobular Dissecting Hepatitis in American Cocker Spaniel Dogs
http://hdl.handle.net/10659/3825
http://hdl.handle.net/10659/38258cc0d9f5-d12d-4ad6-b034-c3340f21feb2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
S-2014-167_matsuda.pdf (1.9 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2015-05-12 | |||||
| タイトル | ||||||
| タイトル | Histological and Immunohistochemical Evaluations of Lobular Dissecting Hepatitis in American Cocker Spaniel Dogs | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | canine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | fibrosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hepatitis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | immunohistochemistry | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
MIZOOKU, Hiroko
× MIZOOKU, Hiroko× KAGAWA, Yumiko× 松田, 一哉× 岡本, 実× TANIYAMA, Hiroyuki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Histological and immunohistochemical evaluations of lobular dissecting hepatitis (LDH) were performed in nine American cocker spaniel dogs. Histological examination showed diffuse fibrosis with weak inflammatory reaction of extensive neutrophils, macrophages, lymphocytes and plasma cells. Immunohistochemical examination revealed that the myofibroblastic cells positive for anti-α-smooth muscle actin and anti-vimentin antibodies produced reticular and collagen fibers and brought about the dissection of hepatic cords and diffuse disappearance of hepatocytes. Reticular fibers invading between hepatocytes and the surrounding small group of hepatocytes were strongly positive for anti-collagen type III and anti-collagen type IV antibodies. The positivity to anti-fibronectin and anti-laminin antibodies was frequently continuous on the basement membrane of the sinusoids of the remaining hepatic cords and between the hepatocytes. Positive findings for anti-E-cadherin antibody were not observed between the hepatocytes showing positive findings for anti-collagen type III and anti-collagen type IV antibodies. These results may explain the expression of fibronectin and laminin that occurs prior to the invasion of reticular fibers between hepatocytes. The present study further suggests that expression of an extracellular matrix mainly containing fibronectin and laminin between the hepatocytes and proliferation of collagen fibers and reticular fibers have a major role in the rupture of the hepatic cords and disappearance of hepatocytes. | |||||
| 書誌情報 |
Journal of Veterinary Medical Science 巻 75, 号 5, p. 597-603, 発行日 2013-05 |
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| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1292/jvms.12-0447 | |||||
| 権利 | ||||||
| 権利情報 | ©2013 The Japanese Society of Veterinary Science | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 日本獣医学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
