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Modifications of the defense and remodeling functionalities of bovine neutrophils inside the mammary gland of milk stasis cows received a commercial dry-cow treatment
http://hdl.handle.net/10659/3034
http://hdl.handle.net/10659/3034a3decf27-8c5c-4b45-a097-17d1e62b9896
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2013-06-04 | |||||
タイトル | ||||||
タイトル | Modifications of the defense and remodeling functionalities of bovine neutrophils inside the mammary gland of milk stasis cows received a commercial dry-cow treatment | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Peripheral PMN | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mammary secretion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Drying-off cows | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | In vitro | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Free radical | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Remodeling | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MMP 9 degranulation | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Yu, Ting-Chieh
× Yu, Ting-Chieh× Chang, Chai-Ju× Ho, Chin-Han× Peh, Huo-Cheng× Chen, Shuen-Ei× Liu, Wen-Bor× Peng, Hsin-Yi× Piamya, Piya× Chen, Ming-Tsao× Nagahata, Hajime |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | An appropriate length of milk stasis between two consecutive lactations of dairy cows is crucial for sustainable milk production. This dry period of cows allows extensive remodeling and sufficient cell renewal in mammary gland. Nevertheless, early dry period is one of the most risky stages in cow lactation cycle to intramammary infection. Dry-cow treatment through teats is, therefore, widely practiced at the commencement of milk stasis. Neutrophils are the most abundant cellular components in cow mammary secretion during early dry period, which in turn attribute to the meanwhile elevation of somatic cell counts and matrix metalloproteinase-9 (MMP-9) level. This study used bovine peripheral neutrophils as a cell model to examine the mode of modifications in their defense and remodeling functionalities after infiltration into mammary gland during early dry period. Results indicate a dose-dependent suppression of phorbol 12-myristate 13-acetate-stimulated free radical production and induction of MMP 9 degranulation in bovine peripheral neutrophils exposure to the d 7-dry secretion of cows received dry cow treatment at d 0 in milk stasis. Meanwhile, an enhancement of plasminogen activation and TNF-α shedding on bovine peripheral neutrophils were also observed. These two cellular events might be involved in the functional modifications on infiltrated neutrophils during early dry period. In conclusion, the opposite trend of modifications in the defense and matrix remodeling functionalities of neutrophils inside the mammary gland of cows at early dry period reflect the collaboration of infiltrated neutrophils for promoting extensive glandular remodeling at minimum compromise of local defense during the acute involution period without apparent disturbance by dry cow treatment. | |||||
書誌情報 |
Veterinary Immunology and Immunopathology 巻 144, 号 3-4, p. 210-219, 発行日 2011-12 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0165-2427 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.vetimm.2011.09.006 | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |