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Proteome Analysis of Cerebrospinal Fluid in Healthy Beagles and Canine Encephalitis
http://hdl.handle.net/10659/3475
http://hdl.handle.net/10659/3475ebce6032-2822-4192-86bc-bd043ddd9903
名前 / ファイル | ライセンス | アクション |
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S-2013-121_nakade.pdf (1.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-06-16 | |||||
タイトル | ||||||
タイトル | Proteome Analysis of Cerebrospinal Fluid in Healthy Beagles and Canine Encephalitis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 2DE | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | canine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CSF | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | encephalitis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | proteome | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
NAKAMURA, Kozo
× NAKAMURA, Kozo× 宮庄, 拓× NOMURA, Sachiko× YOKOTA, Hiroshi× NAKADE, Tetsuya |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We performed proteomics analysis of the cerebrospinal fluid (CSF) of healthy dogs and dogs with meningoencephalitis of unknown etiology (MUE). By comparing two-dimensional electrophoreses (2DE), an upregulated spot was found in MUE dogs. This protein was identified as a neuron-specific enolase (NSE) by analysis with MALDI-TOF mass spectrometry. In comparing dot blots using an antibody against NSE, the NSE levels in the CSF of MUE dogs was significantly higher than that of the controls. NSE is a diagnostic marker of neuroendocrine tumors, brain injury and spinal cord trauma in humans. It seems that the NSE concentration in the CSF is increased by cellular destruction in canine encephalitis. Though elevation of NSE may not be specific in canine encephalitis because the NSE level was increased in other CNS diseases, further study including measurement with serum is necessary. | |||||
書誌情報 |
Journal of Veterinary Medical Science 巻 74, 号 6, p. 751-756, 発行日 2012-06 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0916-7250 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1292/jvms.11-0474 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 日本獣医学会 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |