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A non-selective cationic channel activated by diacylglycerol in mouse intestinal myocytes
http://hdl.handle.net/10659/1821
http://hdl.handle.net/10659/18210ed14966-6c99-470f-a177-04af5b33549c
名前 / ファイル | ライセンス | アクション |
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S-519_Kitazawa.pdf (289.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-03-31 | |||||
タイトル | ||||||
タイトル | A non-selective cationic channel activated by diacylglycerol in mouse intestinal myocytes | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | muscarinic receptor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | M_3 subtype | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | diacylglycerol | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cationic channels | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | intestinal smooth muscle | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Sakamoto, Takashi
× Sakamoto, Takashi× Matsuyama, Hayato× Yamamoto, Masayuki× Tanahashi, Yasuyuki× Kitazawa, Takio× Taneike, Tetsuro× Komori, Seiichi× Unno, Toshihiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Application of 1-oleoyl-2-acetyl-sn-glycerol (OAG), an analogue of diacylglycerol (DAG) formed via M_3 muscarinic receptors, induced inward cationic currents via a protein kinase C-independent mechanism and produced membrane depolarization with increased action potential discharges in mouse intestinal myocytes. Outside-out patches from the myocytes responded to OAG with openings of 115-pS channels characterized by a mean open time (O_τ) of 0.15 ms. M3 receptor stimulation is reportedly capable of causing brief openings (O_τ = 0.23 ms) of 120-pS cationic channels in intestinal myocytes, thus the present results strongly support the idea that the M_3-mediated 120-pS channel opening is brought about via DAG-dependent mechanisms. | |||||
書誌情報 |
European journal of pharmacology 巻 599, 号 1-3, p. 54-57, 発行日 2008-11 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0014-2999 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ejphar.2008.09.039 | |||||
権利(URI) | ||||||
権利情報 | http://dx.doi.org/10.1016/j.ejphar.2008.09.039 | http://dx.doi.org/10.1016/j.ejphar.2008.09.039 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |