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アイテム
Enhanced expression of cytokines/chemokines in cerebrospinal fluids in mumps meningitis in children
http://hdl.handle.net/10659/3032
http://hdl.handle.net/10659/3032ed0a18e4-7e91-49f4-ba3b-47019a0a3160
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-06-04 | |||||
| タイトル | ||||||
| タイトル | Enhanced expression of cytokines/chemokines in cerebrospinal fluids in mumps meningitis in children | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | chemokine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cytokine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | meningitis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mumps | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Asano, Takeshi
× Asano, Takeshi× Ichiki, Kunihiko× Koizumi, Shinya× Kaizu, Kiyohiko× Hatori, Takayuki× Fujino, Osamu× Mashiko, Kunihiro× Sakamoto, Yuichiro× Miyasho, Taku× Fukunaga, Yoshitaka |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: The mumps virus is frequently the causative agent in aseptic meningitis and mumps has still prevailed in Japan. We compared data obtained from patients with mumps meningitis and patients with aseptic meningitis caused by other viruses in order to identify mumps meningitis-specific cytokine/chemokine alterations in cerebrospinal fluide (CSF). Methods: We elucidated the cytokine/chemokine network based on the cytokine/chemokine profiles in CSF from children with mumps meningitis and meningitis due to other viral infections using multiplex cytokine measurement. Seventeen cytokines/chemokines, namely interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12 (p70), IL-13, IL-17, interferon (IFN)-γ, tumor necrosis factor (TNF)-α, granulocyte colony-stimulating factor (G-CSF), granulocyte monocyte colony-stimulating factor (GM-CSF), monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1β (MIP-1β), were measured simultaneously in CSF supernatants from eight children with mumps meningitis, 11 children with other types of viral meningitis and eight children with fever without neurological complications such as convulsion. Results: We found that IL-8, IL-10, IL-12, IL-13 and IFN-γ showed a statistically significant increase in CSF from mumps meningitis when compared to other types of viral meningitis and fever without neurological complications. Conclusion: Mumps meningitis may induce a distinct immunological response when compared with other types of viral meningitis. | |||||
| 書誌情報 |
Pediatrics International 巻 53, 号 2, p. 143-146, 発行日 2011-04 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1442-200X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1111/j.1442-200X.2010.03215.x | |||||
| 出版者 | ||||||
| 出版者 | Wiley-Blackwell | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
