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Expression of Two Novel Cytochrome P450 3A131 and 3A132 in Liver and Small Intestine of Domestic Cats
http://hdl.handle.net/10659/3184
http://hdl.handle.net/10659/31844597c4ca-ebc3-4fc0-8813-f4dbb0dbc918
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2013-06-04 | |||||
タイトル | ||||||
タイトル | Expression of Two Novel Cytochrome P450 3A131 and 3A132 in Liver and Small Intestine of Domestic Cats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | carnivore | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cytochrome P450 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | domestic cat | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | felid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | xenobiotics | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
HONDA, Kouichi
× HONDA, Kouichi× KOMATSU, Tetsuya× KOYAMA, Fumika× KUBOTA, Akira× KAWAKAMI, Kei× ASAKURA, Hiroyuki× UNO, Yasuhiro× KITAZAWA, Takio× HIRAGA, Takeo× TERAOKA, Hiroki |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Cytochrome P450 3A (CYP3A) is the major subfamily of CYP, one of the most important metabolizing enzymes for drugs in humans and other mammals. We found two novel CYP3A genes, CYP3A131 and CYP3A132 in domestic cats (Felis catus). Both feline CYP3A proteins consist of 504 deduced amino acids and show high identity with canine CYP3A homologues and those of some artiodactyls. CYP3A131 transcripts were expressed predominantly in liver and small intestine, and to a negligible extent in other tissues, including brain, heart, kidney and lung. CYP3A132 expression was only detected in liver with much lesser amount. These results suggest the possible major role of CYP3A131 in xenobiotic metabolism including first-pass effects in domestic cats. | |||||
書誌情報 |
The journal of veterinary medical science 巻 73, 号 11, p. 1489-1492, 発行日 2011-11 |
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DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1292/jvms.11-0098 | |||||
出版者 | ||||||
出版者 | 日本獣医学会 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |