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Truncated yet functional viral protein produced via RNA polymerase slippage implies underestimated coding capacity of RNA viruses
http://hdl.handle.net/10659/00005403
http://hdl.handle.net/10659/0000540377ec85b7-e859-478c-9afd-10b480895685
名前 / ファイル | ライセンス | アクション |
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R-2017-101_Komoda.pdf (1.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-04-12 | |||||
タイトル | ||||||
タイトル | Truncated yet functional viral protein produced via RNA polymerase slippage implies underestimated coding capacity of RNA viruses | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
薦田, 優香
× 薦田, 優香× Choi, Sun Hee× Sato, Masanao× Atsumi, Go× Abe, Junya× Fukuda, Junya× Honjo, Mie N.× Nagano, Atsushi J.× Komoda, Keisuke× Nakahara, Kenji S.× Uyeda, Ichiro× Naito, Satoshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | RNA viruses use various strategies to condense their genetic information into small genomes. Potyviruses not only use the polyprotein strategy, but also embed an open reading frame, pipo, in the P3 cistron in the -1 reading frame. PIPO is expressed as a fusion protein with the N-terminal half of P3 (P3N-PIPO) via transcriptional slippage of viral RNA-dependent RNA polymerase (RdRp). We herein show that clover yellow vein virus (ClYVV) produces a previously unidentified factor, P3N-ALT, in the +1 reading frame via transcriptional slippage at a conserved G_<1-2>A_<6-7> motif, as is the case for P3N-PIPO. The translation of P3N-ALT terminates soon, and it is considered to be a C-terminal truncated form of P3. In planta experiments indicate that P3N-ALT functions in cell-to-cell movement along with P3N-PIPO. Hence, all three reading frames are used to produce functional proteins. Deep sequencing of ClYVV RNA from infected plants endorses the slippage by viral RdRp. Our findings unveil a virus strategy that optimizes the coding capacity. | |||||
書誌情報 |
Scientific Reports 巻 6, p. 21411-1-21411-14, 発行日 2016-02 |
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ISBN | ||||||
識別子タイプ | ISBN | |||||
関連識別子 | 2045-2322 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | http://dx.doi.org/10.1038/srep21411 | |||||
権利(URI) | ||||||
権利情報 | http://creativecommons.org/licenses/by/4.0/ | http://creativecommons.org/licenses/by/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Macmillan Publishers Limited | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |