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Effects of ghrelin and motilin on smooth muscle contractility of the isolated gastrointestinal tract from the bullfrog and Japanese fire belly newt
http://hdl.handle.net/10659/00005411
http://hdl.handle.net/10659/00005411506117f6-bea6-48bd-b2d8-be56899d0642
名前 / ファイル | ライセンス | アクション |
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R-2017-124_Kitazawa.pdf (1.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-04-12 | |||||
タイトル | ||||||
タイトル | Effects of ghrelin and motilin on smooth muscle contractility of the isolated gastrointestinal tract from the bullfrog and Japanese fire belly newt | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Growth hormone secretagogue receptor 1a | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ghrelin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Gastrointestinal motility | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Motilin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bullfrog | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Japanese fire belly newt | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kitazawa, Takio
× Kitazawa, Takio× Shimazaki, Misato× Kikuta, Ayumi× Yaosaka, Noriko× TERAOKA, Hiroki× Kaiya, Hiroyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Ghrelin has been identified in some amphibians and is known to stimulate growth hormone release and food intake as seen in mammals. Ghrelin regulates gastrointestinal motility in mammals and birds. The aim of this study was to determine whether ghrelin affects gastrointestinal smooth muscle contractility in bullfrogs (anuran) and Japanese fire belly newts (urodelian) in vitro. Neither bullfrog ghrelin nor rat ghrelin affected longitudinal smooth muscle contractility of gastrointestinal strips from the bullfrog. Expression of growth hormone secretagogue receptor 1a (GHS-R1a) mRNA was confirmed in the bullfrog gastrointestinal tract, and the expression level in the gastric mucosa was lower than that in the intestinal mucosa. In contrast, some gastrointestinal peptides, including substance P, neurotensin and motilin, and the muscarinic receptor agonist carbachol showed marked contraction, indicating normality of the smooth muscle preparations. Similar results were obtained in another amphibian, the Japanese fire belly newt. Newt ghrelin and rat ghrelin did not cause any contraction in gastrointestinal longitudinal muscle, whereas substance P and carbachol were effective causing contraction. In conclusion, ghrelin does not affect contractility of the gastrointestinal smooth muscle in anuran and urodelian amphibians, similar to results for rainbow trout and goldfish (fish) but different from results for rats and chickens. The results suggest diversity of ghrelin actions on the gastrointestinal tract across animals. This study also showed for the first time that motilin induces gastrointestinal contraction in amphibians. | |||||
書誌情報 |
General and Comparative Endocrinology 巻 232, p. 51-59, 発行日 2016-06 |
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ISBN | ||||||
識別子タイプ | ISBN | |||||
関連識別子 | 0016-6480 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | http://dx.doi.org/10.1016/j.ygcen.2015.12.013 | |||||
権利 | ||||||
権利情報 | © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license | |||||
権利(URI) | ||||||
権利情報 | http://creativecommons.org/licenses/by-nc-nd/4.0/ | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
出版者 | ||||||
出版者 | Elsevier Inc. | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |