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Change in the responsiveness of interferon-stimulated genes during early pregnancy in cows with Borna virus-1 infection
http://hdl.handle.net/10659/00005434
http://hdl.handle.net/10659/0000543491b1de5b-af14-4ff3-8ec2-43583fc60d48
名前 / ファイル | ライセンス | アクション |
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R-2017-203_Hagiwara.pdf (385.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-04-12 | |||||
タイトル | ||||||
タイトル | Change in the responsiveness of interferon-stimulated genes during early pregnancy in cows with Borna virus-1 infection | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Interferon-stimulated gene | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IFN-τ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pregnant | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Borna disease virus | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Takino, Tadashi
× Takino, Tadashi× Okamura, Taku× Ando, Tatsuya× 萩原, 克郎 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | [Background] Borna disease virus is a neurotropic pathogen and infects the central nervous system. This virus infected a variety of animal species including cows. The most of cows infected with Borna disease virus 1 (BoDV-1) exhibit subclinical infection without any neurological symptoms throughout their lifetime. We previously reported on the low conception rates in-seropositive cows. Interferon-τ (IFN-τ) plays an important role in stable fertilization, and is produced from the fetal side following embryo growth at 15–40 days of pregnancy. IFN-τ induces the expression of interferon-stimulated gene (ISG) 15 and Mx2 in peripheral blood mononuclear cells (PBMCs). To understand the embryo growth and maternal reaction during early pregnancy in cows with BoDV-1 infection, we aimed to assess the gene expression of ISG15 and Mx2 from PBMCs in BoDV-1-seropositive cows. [Results] None of the cows showed any clinical and neurological symptoms. Among the cows that conceived, the expressions of the ISG15 and Mx2 genes were greater in the BoDV-1-seropositive cows than in the BoDV-1-seronegative cows; the difference was significant between the cows that conceived and those that did not (P < 0.05). [Conclusions] The expression of ISG15 and Mx2 genes during early pregnancy significantly increased in the BoDV-1-seropositive cows and may be important for the maintenance of stable pregnancy in BoDV-1-infected cows. In contrast, the gene expression levels of ISG15 and Mx2 did not significantly increase during early pregnancy in BoDV-1-seronegative cows. Thus, BoDV-1 infection may lead to instability in the maintenance of early pregnancy by interfering with INF-τ production. | |||||
書誌情報 |
BMC veterinary research 巻 12, 号 1, p. 253-1-253-4, 発行日 2016-11 |
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ISBN | ||||||
識別子タイプ | ISBN | |||||
関連識別子 | 1746-6148 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | http://dx.doi.org/10.1186/s12917-016-0883-5 | |||||
権利 | ||||||
権利情報 | © The Author(s). 2016 | |||||
権利(URI) | ||||||
権利情報 | https://creativecommons.org/licenses/by/4.0/ | https://creativecommons.org/licenses/by/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | BioMed Central | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |