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Neutralizing activities against seasonal influenza viruses in human intravenous immunoglobulin
http://hdl.handle.net/10659/00005884
http://hdl.handle.net/10659/00005884b11fa536-2d55-43c3-9e61-933e1cc46223
名前 / ファイル | ライセンス | アクション |
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R-2018-31_hagiwara.pdf (701.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-08-08 | |||||
タイトル | ||||||
タイトル | Neutralizing activities against seasonal influenza viruses in human intravenous immunoglobulin | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IVIG | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | influenza | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | seasonal | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | neutralization | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | vaccine | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | IVIG | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | influenza | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | seasonal | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | neutralization | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | vaccine | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Onodera, Hiroyuki
× Onodera, Hiroyuki× Urayama, Takeru× Hirota, Kazue× Maeda, Kazuhiro× Kubota-Koketsu, Ritsuko× Takahashi, Kazuo× 萩原, 克郎× Okuno, Yoshinobu× Ikuta, Kazuyoshi× Yunoki, Mikihiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Influenza viruses A/H1N1, A/H3N2, and B are known seasonal viruses that undergo annual mutation. Intravenous immunoglobulin (IVIG) contains anti-seasonal influenza virus globulins. Although the virus-neutralizing (VN) titer is an indicator of protective antibodies, changes in this titer over extended time periods have yet to be examined. In this study, variations in hemagglutination inhibition (HI) and VN titers against seasonal influenza viruses in IVIG lots over extended time periods were examined. In addition, the importance of monitoring the reactivity of IVIG against seasonal influenza viruses with varying antigenicity was evaluated. A/H1N1, A/H3N2, and B influenza virus strains and IVIG lots manufactured from 1999 to 2014 were examined. The HI titer was measured by standard methods. The VN titer was measured using a micro-focus method. IVIG exhibited significant HI and VN titers against all investigated strains. Our results suggest that the donor population maintains both specific and cross-reactive antibodies against seasonal influenza viruses, except in cases of pandemic viruses, despite major antigen changes. The titers against seasonal influenza vaccine strains, including past strains, were stable over short time periods but increased slowly over time. | |||||
書誌情報 |
Biologics : targets & therapy 巻 2017, 号 11, p. 23-30, 発行日 2017-03 |
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ISBN | ||||||
識別子タイプ | ISBN | |||||
関連識別子 | 1177-5475 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | http://dx.doi.org/10.2147/BTT.S123831 | |||||
権利(URI) | ||||||
権利情報 | https://creativecommons.org/licenses/by-nc/3.0/ | https://creativecommons.org/licenses/by-nc/3.0/ | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Dove Medical Press Limited. | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |