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In Vitro Study of Endotoxin Adsorption by a Polymyxin B-Immobilized Fiber Column
http://hdl.handle.net/10659/00006297
http://hdl.handle.net/10659/00006297e7ec48ec-6512-47b1-9d8a-38698f88eb99
名前 / ファイル | ライセンス | アクション |
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R-2019-3_sakai.pdf (351.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-02-26 | |||||
タイトル | ||||||
タイトル | In Vitro Study of Endotoxin Adsorption by a Polymyxin B-Immobilized Fiber Column | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Polymyxin B-immobilized fiber | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Endotoxin adsorption | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Continuous endotoxin injection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Adsorption saturation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 24-h hemoperfusion | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Polymyxin B-immobilized fiber | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Endotoxin adsorption | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Continuous endotoxin injection | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Adsorption saturation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | 24-h hemoperfusion | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yamashita, Chizuru
× Yamashita, Chizuru× Moriyama, Kazuhiro× Hasegawa, Daisuke× Kato, Yu× Sakai, Toshikazu× Kawaji, Takahiro× Shimomura, Yasuyo× Kurimoto, Yasuyoshi× Nagata, Mariko× Nishida, Osamu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Polymyxin B-immobilized fiber (PMX-F) columns are used as therapeutic interventions for septic shock. The clinical efficacy has been reported for 2-h applications, but their ability to adsorb endotoxin over longer treatments has not been fully elucidated. We hypothesized that PMX-F columns are capable of endotoxin removal for more than 2 h. Method: We designed closed circuits incorporating either a PMX-F column with an 8.5-mL priming volume (PMX-01R) or a sham-control column, and used inactivated fetal bovine serum as the circulating perfusate. Endotoxin was continuously injected at a fixed rate for 24 h, and perfusate endotoxin concentrations were measured at fixed time points. PMX-01R endotoxin adsorption was calculated from the difference in the endotoxin concentrations. Results: PMX-01R endotoxin adsorption increased continuously in a virtually linear manner. Conclusions: The PMX-01R column showed sustained endotoxin adsorption for at least 24 h. This indicated that PMX-F columns would be capable of clinical endotoxin removal for 24 h. | |||||
書誌情報 |
Blood purification 巻 46, 号 4, p. 269-273, 発行日 2018-10 |
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ISBN | ||||||
識別子タイプ | ISBN | |||||
関連識別子 | 0253-5068 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | http://dx.doi.org/10.1159/000489920 | |||||
権利 | ||||||
権利情報 | © 2018 The Author(s) Published by S. Karger AG, Basel | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Karger AG, Basel | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |