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Brazilian propolis ethanol extract and its component kaempferol induce myeloid-derived suppressor cells from macrophages of mice in vivo and in vitro
http://hdl.handle.net/10659/00006307
http://hdl.handle.net/10659/00006307ef260400-ad81-4da3-9ced-2602db8fa84a
名前 / ファイル | ライセンス | アクション |
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R-2019-43_kitamura.pdf (1.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-02-26 | |||||
タイトル | ||||||
タイトル | Brazilian propolis ethanol extract and its component kaempferol induce myeloid-derived suppressor cells from macrophages of mice in vivo and in vitro | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Propolis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Kaempferol | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Myeloid-derived suppressor cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Macrophage | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Type 2 diabetes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chronic inflammation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Propolis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Kaempferol | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Myeloid-derived suppressor cells | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Macrophage | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Type 2 diabetes | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Chronic inflammation | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
北村, 浩
× 北村, 浩× Saito, Natsuko× Fujimoto, Junpei× Nakashima, Ken-ichi× Fujikura, Daisuke |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 【Background】 Brazilian green propolis is produced by mixing secretions from Africanized honey bees with exudate, mainly from Baccharis dracunculifolia. Brazilian propolis is especially rich in flavonoids and cinammic acid derivatives, and it has been widely used in folk medicine owing to its anti-inflammatory, anti-viral, tumoricidal, and analgesic effects. Moreover, it is applied to prevent metabolic disorders, such as type 2 diabetes and arteriosclerosis. Previously, we demonstrated that propolis ethanol extract ameliorated type 2 diabetes in a mouse model through the resolution of adipose tissue inflammation. The aims of this study were to identify the immunosuppressive cells directly elicited by propolis extract and to evaluate the flavonoids that induce such cells.【Methods】 Ethanol extract of Brazilian propolis (PEE; 100 mg/kg i.p., twice a week) was injected into lean or high fat-fed obese C57BL/6 mice or C57BL/6 ob/ob mice for one month. Subsequently, immune cells in visceral adipose tissue and the peritoneal cavity were monitored using FACS analysis. Isolated macrophages and the macrophage-like cell line J774.1 were treated with PEE and its constituent components, and the expression of immune suppressive myeloid markers were evaluated. Finally, we injected one of the identified compounds, kaempferol, into C57BL/6 mice and performed FACS analysis on the adipose tissue.【Results】 Intraperitoneal treatment of PEE induces CD11b+, Gr-1+ myeloid-derived suppressor cells (MDSCs) in visceral adipose tissue and the peritoneal cavity of lean and obese mice. PEE directly stimulates cultured M1 macrophages to transdifferentiate into MDSCs. Among twelve compounds isolated from PEE, kaempferol has an exclusive effect on MDSCs induction in vitro. Accordingly, intraperitoneal injection of kaempferol causes accumulation of MDSCs in the visceral adipose tissue of mice.【Conclusion】 Brazilian PEE and its compound kaempferol strongly induce MDSCs in visceral adipose tissue at a relatively early phase of inflammation. Given the strong anti-inflammatory action of MDSCs, the induction of MDSCs by PEE and kaempferol is expected to be useful for anti-diabetic and anti-inflammatory therapies. | |||||
書誌情報 |
BMC Complementary and Alternative Medicine 巻 18, p. 138-1-138-11, 発行日 2018-05 |
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ISBN | ||||||
識別子タイプ | ISBN | |||||
関連識別子 | 1472-6882 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | http://dx.doi.org/10.1186/s12906-018-2198-5 | |||||
権利 | ||||||
権利情報 | © The Author(s). 2018 | |||||
権利(URI) | ||||||
権利情報 | http://creativecommons.org/licenses/by/4.0/ | http://creativecommons.org/licenses/by/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | BioMed Central Ltd | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |