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Innate immune response of bovine mammary epithelial cells to Mycoplasma bovis
http://hdl.handle.net/10659/00006320
http://hdl.handle.net/10659/00006320ff3800eb-b6c0-4b57-9623-3b1855c803b6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
R-2019-78_iwano.pdf (617.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2020-02-26 | |||||
| タイトル | ||||||
| タイトル | Innate immune response of bovine mammary epithelial cells to Mycoplasma bovis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Mycoplasma bovis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | bovine mammary epithelial cells | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cytokines | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | innate immunity | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | microarray analysis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Mycoplasma bovis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | bovine mammary epithelial cells | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | cytokines | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | innate immunity | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | microarray analysis | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Gondaira, Satoshi
× Gondaira, Satoshi× 樋口, 豪紀× 岩野, 英知× Nishi, Koji× Nebu, Takanori× Nakajima, Keiichi× Nagahata, Hajime |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Mycoplasma spp. are contagious bacteria, and mycoplasmal mastitis is a serious productivity problem on dairy farms. Bovine mammary epithelial cells (bMECs) have an important role in the elimination of pathogens, but the effect of Mycoplasma bovis on bMECs has not been fully described. To elucidate the immune response against intramammary infection by M. bovis, we undertook microarray analysis to examine and profile mRNA expression in bMECs after stimulation with M. bovis. We also compared the effects of M. bovis, Staphylococcus aureus, and Escherichia coli on immune-related mRNA expression in bMECs. Transcriptome analysis indicated a significant decrease in the level of mRNA-encoding lysine-specific demethylase 4D, suggesting that the immune response is suppressed by a decrease in histone demethylase activity. Interleukin (IL)-1β, IL-6, tumor necrosis factor alpha, toll-like receptor (TLR) 2, and TLR4 mRNA expression levels were significantly increased in bMECs stimulated with heat-killed M. bovis, but the expression levels were lower than those following stimulation by heat-killed S. aureus or E. coli. Our results suggest that M. bovis weakly affects mRNA expression in bMECs compared to the effects of E. coli or S. aureus. Moreover, live M. bovis may induce suppression of the immune response in bMECs. | |||||
| 書誌情報 |
Journal of veterinary science 巻 19, 号 1, p. 79-87, 発行日 2018-01 |
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| ISBN | ||||||
| 識別子タイプ | ISBN | |||||
| 関連識別子 | 1229-845X | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.4142/jvs.2018.19.1.79 | |||||
| 権利 | ||||||
| 権利情報 | © 2018 The Korean Society of Veterinary Science | |||||
| 権利（URI） | ||||||
| 権利情報 | http://creativecommons.org/licenses/by-nc/4.0 | http://creativecommons.org/licenses/by-nc/4.0 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | Korean Society of Veterinary Science | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
