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Regulation of Constitutive Interferon-Stimulated Genes (Isgs) in Tumor Cells Contributes to Enhanced Antitumor Response of Newcastle Disease Virus-Infected Tumor Vaccines
http://hdl.handle.net/10659/00006335
http://hdl.handle.net/10659/00006335df7d6709-3049-40f6-a5aa-3336920129b2
名前 / ファイル | ライセンス | アクション |
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R-2019-118_hagiwara.pdf (1.9 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-02-26 | |||||
タイトル | ||||||
タイトル | Regulation of Constitutive Interferon-Stimulated Genes (Isgs) in Tumor Cells Contributes to Enhanced Antitumor Response of Newcastle Disease Virus-Infected Tumor Vaccines | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Newcastle disease virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | tumor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | vaccines | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ISG | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ruxolitinib | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Newcastle disease virus | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | tumor | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | vaccines | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | ISG | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | ruxolitinib | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Takamura-Ishii, Mai
× Takamura-Ishii, Mai× Nakaya, Takaaki× 萩原, 克郎 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Newcastle disease virus (NDV) is an oncolytic virus. As immunogenicity of tumor cells is enhanced by NDV infection, recombinant NDV-infected tumor vaccines (rNDV-TV) are effective methods for inducing specific immunity. However, several tumor cells resist NDV infection, and tumor specific immunity is not sufficiently induced by rNDV-TV. Therefore, we clarified the factor contributing to the suppression of NDV infection and attempted to improve rNDV-TV. Initially we investigated the correlation between the NDV infection rate and interferon-related gene expression in six murine tumor cell lines. A significant negative correlation was observed between the constitutive gene expression of Interferon-stimulated genes (ISGs) and NDV infectivity. The NDV infection rate was examined in each tumor cell treated with the Janus kinase (JAK) inhibitor ruxolitinib (Rux). Furthermore, we evaluated the Th1 response induction by Rux-treated rNDV-TV (rNDV-TV-Rux). In Rux-treated tumor cells, Oasl2 gene expression was significantly decreased and viral infectivity was increased. In immunized mice, the number of CD8+ cells, and those expressing the IFN-γ gene, were significantly increased as compared with Rux-untreated rNDV-TV. The infectivity of the virus was dependent on the degree of ISGs expression in tumor cells. To remedy for this problem, rNDV-TV-Rux was expected to have a Th1 immune response. | |||||
書誌情報 |
Cancers 巻 10, 号 6, p. 186-1-186-13, 発行日 2018-06 |
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ISBN | ||||||
識別子タイプ | ISBN | |||||
関連識別子 | 2072-6694 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | http://dx.doi.org/10.3390/cancers10060186 | |||||
権利 | ||||||
権利情報 | © 2018 by the authors. Licensee MDPI, Basel, Switzerland. | |||||
権利(URI) | ||||||
権利情報 | http://creativecommons.org/licenses/by/4.0/ | http://creativecommons.org/licenses/by/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | MDPI | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |