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A Simple Mechanism Based on Amino Acid Substitutions is not a Critical Determinant of High Mortality of Japanese Encephalitis Virus Infection in Mice
http://hdl.handle.net/10659/00006342
http://hdl.handle.net/10659/00006342459a6f2c-abfb-4a5d-baa2-73c582e50efd
名前 / ファイル | ライセンス | アクション |
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R-2019-138_uchida.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-02-26 | |||||
タイトル | ||||||
タイトル | A Simple Mechanism Based on Amino Acid Substitutions is not a Critical Determinant of High Mortality of Japanese Encephalitis Virus Infection in Mice | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Japanese encephalitis virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pathogenicity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mouse | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | recombinant | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | amino acid substitution | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Japanese encephalitis virus | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | pathogenicity | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | mouse | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | recombinant | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | amino acid substitution | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Takamatsu, Yuki
× Takamatsu, Yuki× 内田, 玲麻× Raekiansyah, Muhareva× Luz, Mark Anthony× Morita, Kouichi× Hayasaka, Daisuke |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | For the development of effective treatment strategies for Japanese encephalitis (JE), it is important to identify the viral factors causing severe disease during JE virus (JEV) infection. In this study, we assessed whether amino acid substitutions are critical factors for higher mortality of JaTH160 compared with JaOArS982 in mice using the technique of infectious cDNA clones. We raised the possibility that two amino acids of C_<124> and NS3_<482> of JaTH160 may contribute to increased mortality in mice. However, simultaneous substitutions of these amino acids did not significantly increase the virulence of JaOArS982, suggesting that high mortality due to JaTH160 viral infection cannot be simply attributed to the specific amino acids. Multiple and complex, but not simple, mechanisms may induce the high mortality of JaTH160 infection in mice. | |||||
書誌情報 |
Viruses 巻 10, 号 2, p. 62-1-62-10, 発行日 2018-02 |
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ISBN | ||||||
識別子タイプ | ISBN | |||||
関連識別子 | 1999-4915 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | http://dx.doi.org/10.3390/v10020062 | |||||
権利 | ||||||
権利情報 | © 2018 by the authors. Licensee MDPI, Basel, Switzerland. | |||||
権利(URI) | ||||||
権利情報 | http://creativecommons.org/licenses/by/4.0/ | http://creativecommons.org/licenses/by/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | MDPI | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |