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Genetic diversity of cytochrome P450 3A with different metabolic activity in domestic cats
http://hdl.handle.net/10659/00006659
http://hdl.handle.net/10659/00006659e1451a60-89a3-41f6-b8ef-b496a5e6dfd2
名前 / ファイル | ライセンス | アクション |
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R-2020-174_teraoka.pdf (699.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-11-18 | |||||
タイトル | ||||||
タイトル | Genetic diversity of cytochrome P450 3A with different metabolic activity in domestic cats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cytochrome P450 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | domestic cat | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | polymorphism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | xenobiotic | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | cytochrome P450 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | domestic cat | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | polymorphism | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | xenobiotic | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
SUGIYAMA, Souta
× SUGIYAMA, Souta× UNO, Yasuhiro× 天野, 朋子× KITAZAWA, Takio× TERAOKA, Hiroki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Knowledge on genetic polymorphisms of metabolising enzymes including cytochrome P450 (CYP) is very limited in cats. We investigated polymorphisms in CYP3A131, one of the major CYP isoforms in the feline liver and small intestine. Eight non-synonymous variants and one synonymous variant of feline CYP3A131 were identified in 29 cats. A major non-synonymous type was not observed. Metabolic parameters (Km and Vmax) of dibenzylfluorescein hydroxylation were ranged within about 2 times for the identified non-synonymous variants by using a heterologous coexpression system of CYP3A131 and feline cytochrome P450 reductase in Escherichia coli. The results confirmed the polymorphic nature of CYP3A131 as a basis for effective application of medicines and prevention of adverse reactions in the treatment of domestic cats. | |||||
書誌情報 |
Journal of Veterinary Medical Science 巻 81, 号 4, p. 598-600, 発行日 2019-04 |
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ISBN | ||||||
識別子タイプ | ISBN | |||||
関連識別子 | 0916-7250 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1292/jvms.18-0692 | |||||
権利(URI) | ||||||
権利情報 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 日本獣医学会 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |