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Anesthetic effect of a mixture of alfaxalone, medetomidine, and butorphanol for inducing surgical anesthesia in ICR, BALB/c, and C57BL/6 mouse strains
http://hdl.handle.net/10659/00006673
http://hdl.handle.net/10659/000066730fb3b711-956f-4672-9a99-b459b040913d
名前 / ファイル | ライセンス | アクション |
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R-2020-208_oosugi.pdf (1.9 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-11-18 | |||||
タイトル | ||||||
タイトル | Anesthetic effect of a mixture of alfaxalone, medetomidine, and butorphanol for inducing surgical anesthesia in ICR, BALB/c, and C57BL/6 mouse strains | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | alfaxalone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | anesthesia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | butorphanol | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | medetomidine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mice | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | alfaxalone | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | anesthesia | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | butorphanol | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | medetomidine | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | mice | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
TSUKAMOTO, Yoriko
× TSUKAMOTO, Yoriko× YAMADA, Norihide× 三好, 健二郎× 山下, 和人× OHSUGI, Takeo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The anesthetic effects of alfaxalone combined with medetomidine and butorphanol were investigated for ICR, BALB/c, and C57BL/6 mice. Mice were administered a combination of 0.5 or 0.75 mg/kg medetomidine and 5 mg/kg butorphanol with 30 or 40 mg/kg alfaxalone (0.5MBA30, 0.75MBA30 and 0.75MBA40, respectively). The drug combinations were administered subcutaneously and were compared with a widely used combination of 0.3 mg/kg medetomidine, 4 mg/kg midazolam, and 5 mg/kg butorphanol (MMB). All three MBA combinations achieved surgical anesthesia, although the recovery time was longer with 0.75MBA30 and 0.75MBA40 compared with 0.5MBA30. Furthermore, several mice exhibited a considerable jumping reaction immediately after injection with 0.75MBA30 and 0.75MBA40. Therefore, 0.5MBA30 may be suitable for inducing surgical anesthesia in the mouse strains tested. The anesthetic scores for 0.5MBA30 were improved compared with those of MMB in all three mouse strains; however, the body temperature drop in C57BL/6 mice was greater with 0.5MBA30. Our results show that the alfaxalone combination, 0.5MBA30, should allow surgical operations that are more stable in more strains of mice than MMB, although the combination may cause hypothermia, especially in C57BL/6 mice. | |||||
書誌情報 |
Journal of Veterinary Medical Science 巻 81, 号 6, p. 937-945, 発行日 2019-06 |
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ISBN | ||||||
識別子タイプ | ISBN | |||||
関連識別子 | 0916-7250 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1292/jvms.18-0712 | |||||
権利(URI) | ||||||
権利情報 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 日本獣医学会 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |