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Inhibition effect of flavophospholipol on conjugative transfer of the extended-spectrum β-lactamase and vanA genes
http://hdl.handle.net/10659/00006700
http://hdl.handle.net/10659/00006700aba74a08-8e7c-4556-b9e2-8082f1c10274
名前 / ファイル | ライセンス | アクション |
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R-2020-308_usui.pdf (597.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-11-18 | |||||
タイトル | ||||||
タイトル | Inhibition effect of flavophospholipol on conjugative transfer of the extended-spectrum β-lactamase and vanA genes | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kudo, Hayami
× Kudo, Hayami× 臼井, 優× Nagafuji, Wataru× Oka, Kentaro× Takahashi, Motomichi× Yamaguchi, Hiroyuki× Tamura, Yutaka |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Flavophospholipol (FPL) is an antimicrobial feed additive that has been approved for use in livestock animals and has the potential to decrease horizontal dissemination of antimicrobial resistance genes. Since previous studies showed that FPL has an inhibitory effect on plasmid transfer, in vitro experiments have proven the efficacy of FPL in reducing the conjugative transfer of plasmids encoding the extended-spectrum β-lactamase (ESBL) and vanA genes. These are among the most important antimicrobial resistance loci known. ESBL-producing Escherichia coli and vancomycin-resistant Enterococcus faecalis (VRE) were exposed to several concentrations of FPL, and transfer frequency and plasmid curing activity were determined. FPL inhibited the conjugative transfer of plasmids harboring ESBL and vanA genes in a concentration-dependent manner in all strains. Further transfer experiments revealed that FPL could decrease or increase transfer frequency depending on plasmid type when transfer frequency was at low levels. The plasmid curing activity of FPL was also observed in ESBL-producing E. coli in a concentration-dependent manner, suggesting that they partially contribute to the inhibition of conjugative transfer. These results suggest that the use of FPL as a feed additive might decrease the dissemination of ESBL and vanA genes among livestock animals. | |||||
書誌情報 |
The Journal of Antibiotics 巻 72, 号 2, p. 79-85, 発行日 2019-02 |
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ISBN | ||||||
識別子タイプ | ISBN | |||||
関連識別子 | 0021-8820 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1038/s41429-018-0113-4 | |||||
権利 | ||||||
権利情報 | © The Author(s) 2018. | |||||
権利(URI) | ||||||
権利情報 | http://creativecommons.org/licenses/by/4.0 | http://creativecommons.org/licenses/by/4.0 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Springer Nature | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |