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Identification of pheasant ghrelin and motilin and their actions on contractility of the isolated gastrointestinal tract
http://hdl.handle.net/10659/00007047
http://hdl.handle.net/10659/00007047dfff5868-c05c-49b9-9aac-e11f8587958f
名前 / ファイル | ライセンス | アクション |
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R-2021-214_kitazawa.pdf (2.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-02-21 | |||||
タイトル | ||||||
タイトル | Identification of pheasant ghrelin and motilin and their actions on contractility of the isolated gastrointestinal tract | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ghrelin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Motilin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pheasant | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Contraction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Small intestine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Proventriculus | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Ghrelin | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Motilin | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Pheasant | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Contraction | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Small intestine | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Proventriculus | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Zhang, Shuangyi
× Zhang, Shuangyi× Okuhara, Yuji× Iijima, Mio× Takemi, Shota× Sakata, Ichiro× Kaiya, Hiroyuki× TERAOKA, Hiroki× Kitazawa, Takio |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Motilin and ghrelin were identified in the pheasant by molecular cloning, and the actions of both peptides on the contractility of gastrointestinal (GI) strips were examined in vitro. Molecular cloning indicated that the deduced amino acid sequences of the pheasant motilin and ghrelin were a 22-amino acid peptide, FVPFFTQSDIQKMQEKERIKGQ, and a 26-amino acid peptide, GSSFLSPAYKNIQQQKDTRKPTGRLH, respectively. In in vitro studies using pheasant GI strips, chicken motilin caused contraction of the proventriculus and small intestine, whereas the crop and colon were insensitive. Human motilin, but not erythromycin, caused contraction of small intestine. Chicken motilin-induced contractions in the proventriculus and ileum were not inhibited by a mammalian motilin receptor antagonist, GM109. Neither atropine (a cholinergic receptor antagonist) nor tetrodotoxin (a neuron blocker) inhibited the responses of chicken motilin in the ileum but both drugs decreased the responses to motilin in the proventriculus, suggesting that the contractile mechanisms of motilin in the proventriculus was neurogenic, different from that of the small intestine (myogenic). On the other hand, chicken and quail ghrelin did not cause contraction in any regions of pheasant GI tract. Since interaction of ghrelin and motilin has been reported in the house musk shrew, interaction of two peptides was examined. The chicken motilin-induced contractions were not modified by ghrelin, and ghrelin also did not cause any contraction under the presence of motilin, suggesting the absence of interaction in both peptides. In conclusion, both the motilin system and ghrelin system are present in the pheasant. Regulation of GI motility by motilin might be common in avian species. However, absence of ghrelin actions in any GI regions suggests the avian species-related difference in regulation of GI contractility by ghrelin. | |||||
書誌情報 |
General and Comparative Endocrinology 巻 285, 号 1, p. 113294, 発行日 2020-01 |
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DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.ygcen.2019.113294 | |||||
権利 | ||||||
権利情報 | © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license. | |||||
権利(URI) | ||||||
権利情報 | http://creativecommons.org/licenses/by-nc-nd/4.0/ | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
出版者 | ||||||
出版者 | Elsevier Inc. | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |