@article{oai:rakuno.repo.nii.ac.jp:00002027,
 author = {Atiba, Ayman and Nishimura, Mayumi and Kakinuma, Shizuko and Hiraoka, Takeshi and Goryo, Masanobu and Shimada, Yoshiya and Ueno, Hiroshi and Uzuka, Yuji},
 issue = {6},
 journal = {The American Journal of Surgery},
 month = {Jun},
 note = {Article, Background: Delayed wound healing is a significant clinical problem in patients who have had previous irradiation. This study investigated the effectiveness of Aloe vera (Av) on acute radiation-delayed wound healing. Methods :The effect of Av was studied in radiation-exposed rats compared with radiation-only and control rats. Skin wounds were excised on the back of rats after 3 days of local radiation. Wound size was measured on days 0, 3, 6, 9, and 12 after wounding. Wound tissues were examined histologically and the expressions of transforming growth factor β-1 (TGF-β-1) and basic fibroblast growth factor (bFGF) were examined by immunohistochemistry and reverse-transcription polymerase chain reaction. Results: Wound contraction was accelerated significantly by Av on days 6 and 12 after wounding. Furthermore, the inflammatory cell infiltration, fibroblast proliferation, collagen deposition, angiogenesis, and the expression levels of TGF-β-1 and bFGF were significantly higher in the radiation plus Av group compared with the radiation-only group. Conclusions: These data showed the potential application of Av to improve the acute radiation-delayed wound healing by increasing TGF-β-1 and bFGF production.},
 pages = {809--818},
 title = {Aloe vera oral administration accelerates acute radiation-delayed wound healing by stimulating transforming growth factor-β and fibroblast growth factor production},
 volume = {201},
 year = {2011}
}