{"created":"2023-06-19T07:00:38.911953+00:00","id":2029,"links":{},"metadata":{"_buckets":{"deposit":"303aeccf-21cd-4a2e-8f84-20035971ad79"},"_deposit":{"created_by":3,"id":"2029","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2029"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00002029","sets":["9:27:28:29"]},"author_link":["4671","4670","4669","4667","4668"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"200","bibliographicPageStart":"189","bibliographicVolumeNumber":"142","bibliographic_titles":[{"bibliographic_title":"Veterinary Immunology and Immunopathology"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Changes in an individual's immune status are considered major contributing factors towards the morbidity of cancer and mortality of aging. To evaluate age-related changes in the immune status of dogs, the immunophenotypes (CD3, CD4, CD8 and CD21) of peripheral blood lymphocytes were measured in 160 healthy dogs aged from 1 to 17 years, and in 365 dogs with various tumors and at various stages. In healthy dogs, the absolute numbers of white blood cells, lymphocytes, and CD3^+, CD4^+ and CD21^+ lymphocytes decreased significantly with age. The relative percentages of lymphocytes and CD4^+ cells decreased significantly, while CD8^+ cells increased significantly with age. The CD4:CD8 ratio showed a significant age-related decrease. In contrast, dogs with tumors possessed significantly lower absolute numbers and relative percentages of all lymphocyte phenotypes, while the CD4:CD8 ratio was significantly higher than in age-matched controls. The relative percentages of CD3^+ and CD8^+ lymphocytes were significantly lower in dogs with distant metastases compared with dogs without metastases, and the CD4:CD8 ratio increased with advanced stage. These observations illustrate the significant changes in immune status with age and the presence of marked immunological defects in a large-scale study of dogs with advanced tumors.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.vetimm.2011.05.008","subitem_relation_type_select":"DOI"}}]},"item_2_source_id_10":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0165-2427","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Watabe, Ai"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukumoto, Shinya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Komatsu, Takahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Endo, Yoshifumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kadosawa, Tsuyoshi"}],"nameIdentifiers":[{}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"Aging","subitem_subject_scheme":"Other"},{"subitem_subject":"Canine","subitem_subject_scheme":"Other"},{"subitem_subject":"Lymphocyte subsets","subitem_subject_scheme":"Other"},{"subitem_subject":"Tumor stages","subitem_subject_scheme":"Other"},{"subitem_subject":"Tumor types","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Alterations of lymphocyte subpopulations in healthy dogs with aging and in dogs with cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Alterations of lymphocyte subpopulations in healthy dogs with aging and in dogs with cancer"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-06-04"},"publish_date":"2013-06-04","publish_status":"0","recid":"2029","relation_version_is_last":true,"title":["Alterations of lymphocyte subpopulations in healthy dogs with aging and in dogs with cancer"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:58:33.077146+00:00"}