@article{oai:rakuno.repo.nii.ac.jp:00002065,
 author = {WASHIO, Kohei and SHIMAMOTO, Yoshinori and KITAMURA, Hiroshi and 北村, 浩},
 issue = {5},
 journal = {Biomedical Research},
 month = {Oct},
 note = {Article, We investigated the anti-obesity effects of Brazilian green propolis ethanol extract using a mouse model of obesity. Repeated intraperitoneal injection of propolis (100 mg/kg twice a week) caused feeding suppression in C57BL/6 mice, whereas this treatment had negligible effects on C57BL/6 ob/ob mice. Since C57BL/6 ob/ob mice have a missense mutation in the Lep gene, leptin is likely to contribute to the propolis-induced feeding suppression. We found that propolis treatment indeed clearly increased leptin mRNA production in the visceral adipose tissues. Moreover, propolis extract directly elevated leptin expression in differentiated 3T3-L1 adipocytes. Artepillin C, an important organic compound found in Brazilian green propolis, failed to induce leptin mRNA in 3T3-L1 cells. Compounds other than artepillin C in Brazilian propolis must thus cause leptin induction in adipocytes, possibly resulting in the suppression of feeding and obesity.},
 pages = {343--346},
 title = {Brazilian propolis extract increases leptin expression in mouse adipocytes},
 volume = {36},
 year = {2015}
}