{"created":"2023-06-19T07:00:40.428406+00:00","id":2065,"links":{},"metadata":{"_buckets":{"deposit":"0608c6bc-f0fd-420a-abc3-087e6a8020ea"},"_deposit":{"created_by":3,"id":"2065","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2065"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00002065","sets":["9:27:28:29"]},"author_link":["4858","4860","4859"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"346","bibliographicPageStart":"343","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"Biomedical Research"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We investigated the anti-obesity effects of Brazilian green propolis ethanol extract using a mouse model of obesity. Repeated intraperitoneal injection of propolis (100 mg/kg twice a week) caused feeding suppression in C57BL/6 mice, whereas this treatment had negligible effects on C57BL/6 ob/ob mice. Since C57BL/6 ob/ob mice have a missense mutation in the Lep gene, leptin is likely to contribute to the propolis-induced feeding suppression. We found that propolis treatment indeed clearly increased leptin mRNA production in the visceral adipose tissues. Moreover, propolis extract directly elevated leptin expression in differentiated 3T3-L1 adipocytes. Artepillin C, an important organic compound found in Brazilian green propolis, failed to induce leptin mRNA in 3T3-L1 cells. Compounds other than artepillin C in Brazilian propolis must thus cause leptin induction in adipocytes, possibly resulting in the suppression of feeding and obesity.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Biomedical Research"}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2220/biomedres.36.343","subitem_relation_type_select":"DOI"}}]},"item_2_source_id_10":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1880-313X","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"WASHIO, Kohei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SHIMAMOTO, Yoshinori"}],"nameIdentifiers":[{},{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"KITAMURA, Hiroshi","creatorNameLang":"en"},{"creatorName":"北村, 浩","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-09-15"}],"displaytype":"detail","filename":"S-2016-149_kitamura.pdf","filesize":[{"value":"261.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S-2016-149_kitamura.pdf","url":"https://rakuno.repo.nii.ac.jp/record/2065/files/S-2016-149_kitamura.pdf"},"version_id":"27872e51-142a-462a-a03e-0b697e0b35ae"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Brazilian propolis extract increases leptin expression in mouse adipocytes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Brazilian propolis extract increases leptin expression in mouse adipocytes"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-06-09"},"publish_date":"2017-06-09","publish_status":"0","recid":"2065","relation_version_is_last":true,"title":["Brazilian propolis extract increases leptin expression in mouse adipocytes"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-31T01:35:36.496058+00:00"}