@article{oai:rakuno.repo.nii.ac.jp:00002097,
 author = {HAYASHI, Masanobu and HIRAI, Ryou and ISHIHARA, Yuusuke and HORIGUCHI, Noboru and ENDO, Daiji and 遠藤, 大二 and OKUI, Toyo},
 issue = {10},
 journal = {The Journal of Veterinary Medical Science},
 month = {Oct},
 note = {Article, Combined effects of treatment with trientine, a copper-chelating agent, and X-irradiation on development of fibrosarcoma using a murine transplantation model in vivo and on cellular survival in vitro were examined. Copper contents in the tumors and serum of trientine-treated mice were significantly lower than those of untreated mice. The tumor volumes of mouse fibrosarcoma QRsp-11 cells increased more slowly in the trientine-treated and the X-irradiated mice than in the control mice from 10 to 24 days postinoculation. The extent of inhibition of tumor growth by X-irradiation at 3 Gy was similar to that obtained by treatment with trientine. A combination of trientine and X-irradiation at 3 Gy showed inhibitory effects on tumor growth similar to those obtained by X-irradiation at 6 Gy. The results showed that trientine and X-irradiation interacted additively in inhibition of tumor growth. When QRsp-11 cells and mouse and bovine endothelial cells were treated with trientine after X-irradiation, the surviving fractions of the cells with combined treatments were essentially consistent with the products of the surviving fractions of trientine-treated cells and those of X-irradiated cells. When the cells were pretreated with trientine and X-irradiated, the surviving fractions of the pretreated cells were lower than those of cells without treatment.},
 pages = {1039--1045},
 title = {Combined effects of treatment with trientine, a copper-chelating agent, and X-irradiaion on tumor growth in transplantation model of a murine fibrosarcoma},
 volume = {69},
 year = {2007}
}