{"created":"2023-06-19T07:00:41.767328+00:00","id":2097,"links":{},"metadata":{"_buckets":{"deposit":"ffde00c1-e208-43e6-9e6c-7f07fc1cedb5"},"_deposit":{"created_by":3,"id":"2097","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2097"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00002097","sets":["9:27:28:29"]},"author_link":["5059","5056","5060","4569","5057","5058"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"1045","bibliographicPageStart":"1039","bibliographicVolumeNumber":"69","bibliographic_titles":[{"bibliographic_title":"The Journal of Veterinary Medical Science"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Combined effects of treatment with trientine, a copper-chelating agent, and X-irradiation on development of fibrosarcoma using a murine transplantation model in vivo and on cellular survival in vitro were examined. Copper contents in the tumors and serum of trientine-treated mice were significantly lower than those of untreated mice. The tumor volumes of mouse fibrosarcoma QRsp-11 cells increased more slowly in the trientine-treated and the X-irradiated mice than in the control mice from 10 to 24 days postinoculation. The extent of inhibition of tumor growth by X-irradiation at 3 Gy was similar to that obtained by treatment with trientine. A combination of trientine and X-irradiation at 3 Gy showed inhibitory effects on tumor growth similar to those obtained by X-irradiation at 6 Gy. The results showed that trientine and X-irradiation interacted additively in inhibition of tumor growth. When QRsp-11 cells and mouse and bovine endothelial cells were treated with trientine after X-irradiation, the surviving fractions of the cells with combined treatments were essentially consistent with the products of the surviving fractions of trientine-treated cells and those of X-irradiated cells. When the cells were pretreated with trientine and X-irradiated, the surviving fractions of the pretreated cells were lower than those of cells without treatment.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本獣医学会"}]},"item_2_source_id_10":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0916-7250","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"HAYASHI, Masanobu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HIRAI, Ryou"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ISHIHARA, Yuusuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HORIGUCHI, Noboru"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"ENDO, Daiji","creatorNameLang":"en"},{"creatorName":"遠藤, 大二","creatorNameLang":"ja"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"OKUI, Toyo"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-09-15"}],"displaytype":"detail","filename":"S-183_Hayashi.pdf","filesize":[{"value":"776.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S-183_Hayashi.pdf","url":"https://rakuno.repo.nii.ac.jp/record/2097/files/S-183_Hayashi.pdf"},"version_id":"c1b44c4e-b412-4913-a580-65406464ed84"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Combined effects of treatment with trientine, a copper-chelating agent, and X-irradiaion on tumor growth in transplantation model of a murine fibrosarcoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Combined effects of treatment with trientine, a copper-chelating agent, and X-irradiaion on tumor growth in transplantation model of a murine fibrosarcoma"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-03-11"},"publish_date":"2010-03-11","publish_status":"0","recid":"2097","relation_version_is_last":true,"title":["Combined effects of treatment with trientine, a copper-chelating agent, and X-irradiaion on tumor growth in transplantation model of a murine fibrosarcoma"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-31T02:22:16.741992+00:00"}