@article{oai:rakuno.repo.nii.ac.jp:00002112,
 author = {Sakurai, Noritaka and Suzuki, Kazuyuki and Sano, Yuki and Saito, Teruyoshi and Yoshimura, Hisashi and Nishimura, Yukie and Yano, Tomohiro and Sadzuka, Yasuyuki and Asano, Ryuji},
 issue = {5},
 journal = {Molecular Medicine Reports},
 month = {Sep},
 note = {Article, The present study was designed to confirm whether the Bowman-Birk inhibitor (BBI) induces an increase in p27 accumulation without S phase kinase-associated protein 2 (skp2) degradation by means of the expression of connexin (Cx) 43 as a gap junctional intercellular communication (GJIC)-dependent pathway in mice with M5076 ovarian sarcoma. M5076 ovarian sarcomas (1x10^5 cells/animal) were subcutaneously transplanted onto the backs of BDF_1 mice receiving 10, 20 or 40 mg/kg of purified BBI intraperitoneally. Relative tumor weight (p<0.01, r=0.503) was negatively correlated with the dose of BBI. In contrast, the relative density of Cx43 mRNA (p<0.01, r=0.570) and Cx43 (p<0.01, r=0.718) was positively correlated with the dose of BBI, as were p21 (p<0.01, r=0.633), p27 (p<0.01, r=0.561) and skp2 (p<0.01, r=0.733). We therefore suggest that the anti-carcinogenic effects of BBI induce negative growth control by means of an increase in p27 accumulation caused by the expression of Cx43 as a GJIC pathway.},
 pages = {689--693},
 title = {Connexin 43-dependent tumor-suppressing effect of the Bowman-Birk protease inhibitor on M5076 ovarian sarcoma-bearing mice},
 volume = {1},
 year = {2008}
}