{"created":"2023-06-19T07:00:42.391433+00:00","id":2112,"links":{},"metadata":{"_buckets":{"deposit":"37a21f26-0717-4582-915d-dfdd675730c8"},"_deposit":{"created_by":3,"id":"2112","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2112"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00002112","sets":["9:27:28:29"]},"author_link":["5139","5142","5141","5143","5146","5144","5140","5145","5147"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"693","bibliographicPageStart":"689","bibliographicVolumeNumber":"1","bibliographic_titles":[{"bibliographic_title":"Molecular Medicine Reports"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The present study was designed to confirm whether the Bowman-Birk inhibitor (BBI) induces an increase in p27 accumulation without S phase kinase-associated protein 2 (skp2) degradation by means of the expression of connexin (Cx) 43 as a gap junctional intercellular communication (GJIC)-dependent pathway in mice with M5076 ovarian sarcoma. M5076 ovarian sarcomas (1x10^5 cells/animal) were subcutaneously transplanted onto the backs of BDF_1 mice receiving 10, 20 or 40 mg/kg of purified BBI intraperitoneally. Relative tumor weight (p<0.01, r=0.503) was negatively correlated with the dose of BBI. In contrast, the relative density of Cx43 mRNA (p<0.01, r=0.570) and Cx43 (p<0.01, r=0.718) was positively correlated with the dose of BBI, as were p21 (p<0.01, r=0.633), p27 (p<0.01, r=0.561) and skp2 (p<0.01, r=0.733). We therefore suggest that the anti-carcinogenic effects of BBI induce negative growth control by means of an increase in p27 accumulation caused by the expression of Cx43 as a GJIC pathway.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Spandidos Publications"}]},"item_2_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3892/mmr_00000014","subitem_relation_type_select":"DOI"}}]},"item_2_source_id_10":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1791-2997","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sakurai, Noritaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Kazuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sano, Yuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saito, Teruyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshimura, Hisashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishimura, Yukie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yano, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sadzuka, Yasuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Asano, Ryuji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-09-15"}],"displaytype":"detail","filename":"S-552_Suzuki.pdf","filesize":[{"value":"146.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S-552_Suzuki.pdf","url":"https://rakuno.repo.nii.ac.jp/record/2112/files/S-552_Suzuki.pdf"},"version_id":"928595dc-546f-4a3a-9b21-ccc217613f68"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Connexin 43-dependent tumor-suppressing effect of the Bowman-Birk protease inhibitor on M5076 ovarian sarcoma-bearing mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Connexin 43-dependent tumor-suppressing effect of the Bowman-Birk protease inhibitor on M5076 ovarian sarcoma-bearing mice"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-03-31"},"publish_date":"2011-03-31","publish_status":"0","recid":"2112","relation_version_is_last":true,"title":["Connexin 43-dependent tumor-suppressing effect of the Bowman-Birk protease inhibitor on M5076 ovarian sarcoma-bearing mice"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:57:13.553857+00:00"}