@article{oai:rakuno.repo.nii.ac.jp:00002116,
 author = {NAGAHATA, Hajime and 樋口, 豪紀 and INANAMI, Osamu and KUWABARA, Mikinori},
 issue = {10},
 journal = {The Journal of Veterinary Medical Science},
 month = {Oct},
 note = {Article, The present study evaluated the costimulatory effects of complement receptor type 3 (CR3) and Fc receptor for IgG (FcγR) on superoxide production and intracellular signal transduction in bovine neutrophils. Stimulation with opsonized zymosan (OPZ) and heat-aggregated bovine IgG (Agg-IgG) resulted in much greater superoxide production and chemiluminescent (CL) responses in normal neutrophils compared with those stimulated with OPZ or Agg-IgG only. Superoxide production and CL response were closely associated with the stimulant-induced rise of the intracellular calcium ([Ca^2^+]_i) concentration, amount of tyrosine phosphorylated 100 kDa protein, and activation of p38 mitogen-activated protein kinase (p38 MAPK). No costimulatory effect was found for these receptors on superoxide production in CR3-deficient neutrophils. Costimulation of CR3 and FcγR on bovine neutrophils leads to enhancement of superoxide production and their signaling pathways and appears to be associated with enhancement of neutrophil functions.},
 pages = {993--997},
 title = {Costimulating effects of complement receptor type 3 and Fc receptor for IgG(FcR) on superoxide production and signal transduction in bovine neutrophils},
 volume = {69},
 year = {2007}
}