{"created":"2023-06-19T07:00:42.556770+00:00","id":2116,"links":{},"metadata":{"_buckets":{"deposit":"7b1958f3-1dc7-4bc4-9bcb-99819d135949"},"_deposit":{"created_by":3,"id":"2116","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2116"},"status":"published"},"_oai":{"id":"oai:rakuno.repo.nii.ac.jp:00002116","sets":["9:27:28:29"]},"author_link":["5177","4528","5176","4494"],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"997","bibliographicPageStart":"993","bibliographicVolumeNumber":"69","bibliographic_titles":[{"bibliographic_title":"The Journal of Veterinary Medical Science"}]}]},"item_2_description_43":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The present study evaluated the costimulatory effects of complement receptor type 3 (CR3) and Fc receptor for IgG (FcγR) on superoxide production and intracellular signal transduction in bovine neutrophils. Stimulation with opsonized zymosan (OPZ) and heat-aggregated bovine IgG (Agg-IgG) resulted in much greater superoxide production and chemiluminescent (CL) responses in normal neutrophils compared with those stimulated with OPZ or Agg-IgG only. Superoxide production and CL response were closely associated with the stimulant-induced rise of the intracellular calcium ([Ca^2^+]_i) concentration, amount of tyrosine phosphorylated 100 kDa protein, and activation of p38 mitogen-activated protein kinase (p38 MAPK). No costimulatory effect was found for these receptors on superoxide production in CR3-deficient neutrophils. Costimulation of CR3 and FcγR on bovine neutrophils leads to enhancement of superoxide production and their signaling pathways and appears to be associated with enhancement of neutrophil functions.","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本獣医学会"}]},"item_2_source_id_10":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0916-7250","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"NAGAHATA, Hajime"}],"nameIdentifiers":[{},{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"樋口, 豪紀","creatorNameLang":""}],"familyNames":[{"familyNameLang":""}],"givenNames":[{"givenNameLang":""}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"INANAMI, Osamu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KUWABARA, Mikinori"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-09-15"}],"displaytype":"detail","filename":"S-181_Nagahata.pdf","filesize":[{"value":"868.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S-181_Nagahata.pdf","url":"https://rakuno.repo.nii.ac.jp/record/2116/files/S-181_Nagahata.pdf"},"version_id":"bcdd4a81-0641-49ce-9ce3-956c0d8c7513"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Costimulating effects of complement receptor type 3 and Fc receptor for IgG(FcR) on superoxide production and signal transduction in bovine neutrophils","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Costimulating effects of complement receptor type 3 and Fc receptor for IgG(FcR) on superoxide production and signal transduction in bovine neutrophils"}]},"item_type_id":"2","owner":"3","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-03-11"},"publish_date":"2010-03-11","publish_status":"0","recid":"2116","relation_version_is_last":true,"title":["Costimulating effects of complement receptor type 3 and Fc receptor for IgG(FcR) on superoxide production and signal transduction in bovine neutrophils"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-31T01:20:03.554976+00:00"}